ArticleThe Analyst2015
Insulator-based dielectrophoresis with β-galactosidase in nanostructured devices.
Article in The Analyst, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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Who cites it
20 citing papers in PubMed, 49 citations in OpenAlex.
- High-resolution 3D-printed insulator-based dielectrophoresis devices for biomolecular manipulation.Analytical and bioanalytical chemistry · 2026Article
- Protein Manipulation via Dielectrophoresis: Theoretical Principles and Emerging Microfluidic Platforms.Micromachines · 2025Review
- Numerical modeling reveals improved organelle separation for dielectrophoretic ratchet migration.Electrophoresis · 2023Article
- Dielectrophoresis: An Approach to Increase Sensitivity, Reduce Response Time and to Suppress Nonspecific Binding in Biosensors?Biosensors · 2022Review
- Continuous organelle separation in an insulator-based dielectrophoretic device.Electrophoresis · 2022Article
- Protein Dielectrophoresis: A Tale of Two Clausius-Mossottis-Or Something Else?Micromachines · 2022Article
- The latest advances on nonlinear insulator-based electrokinetic microsystems under direct current and low-frequency alternating current fields: a review.Analytical and bioanalytical chemistry · 2022Review
- Particle trapping in electrically driven insulator-based microfluidics: Dielectrophoresis and induced-charge electrokinetics.Electrophoresis · 2021Review
- Insulator Based Dielectrophoresis: Micro, Nano, and Molecular Scale Biological Applications.Sensors (Basel, Switzerland) · 2020Review
- Dielectrophoresis of proteins: experimental data and evolving theory.Analytical and bioanalytical chemistry · 2020Article
- Protein Dielectrophoresis: I. Status of Experiments and an Empirical Theory.Micromachines · 2020Article
- Electrokinetic characterization of synthetic protein nanoparticles.Beilstein journal of nanotechnology · 2020Article
- Analysis of Bacteriophages with Insulator-Based Dielectrophoresis.Micromachines · 2019Article
- A mathematical model of dielectrophoretic data to connect measurements with cell properties.Analytical and bioanalytical chemistry · 2019Article
- On the Impact of Electrostatic Correlations on the Double-Layer Polarization of a Spherical Particle in an Alternating Current Field.Langmuir : the ACS journal of surfaces and colloids · 2018Article
- Refinement of insulator-based dielectrophoresis.The Analyst · 2017Article
- Nanoslit design for ion conductivity gradient enhanced dielectrophoresis for ultrafast biomarker enrichment in physiological media.Biomicrofluidics · 2016Article
- Modelling of electrokinetic phenomena for capture of PEGylated ribonuclease A in a microdevice with insulating structures.Biomicrofluidics · 2016Article
- Protein dielectrophoresis and the link to dielectric properties.Bioanalysis · 2015Review
- Protein Crystallization in an Actuated Microfluidic Nanowell Device.Crystal growth & designArticle
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Insulator-based dielectrophoresis (iDEP) has been explored as a powerful analytical technique in recent years. Unlike with larger entities such as cells, bacteria or organelles, the mechanism of iDEP transport of proteins remains little explored. In this work, we extended the pool of proteins investigated with iDEP in nanostructured devices with β-galactosidase. Our work indicates that β-galactosidase shows concentration due to negative DEP which we compare to DEP response of immunoglobulin G (IgG) encapsulated in micelles also showing negative DEP. Experimental observations are further compared with numerical simulations to elucidate the influence of electrokinetic transport and the magnitude of DEP mobility. Numerical simulations suggest that the DEP mobility calculated using the classical model underestimates the actual contribution of DEP on the experimentally monitored concentration effect of proteins. Moreover, we observed a unique voltage dependent β-galactosidase concentration which we attribute to an additional factor influencing the protein concentration at the nanoconstrictions, namely ion concentration polarization. Our work aids in understanding factors influencing protein iDEP transport which is required for the future development of protein preconcentration or separation methods based on iDEP.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.