Evidence map›Paper›PMID 25479419›Full record

ArticlePloS one2014

MTM-6, a phosphoinositide phosphatase, is required to promote synapse formation in Caenorhabditis elegans.

Vivian R Ericson, Kerri A Spilker, Madina S Tugizova, Kang Shen

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.1field-weighted citation impact, top 55% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Vivian R EricsonDepartment of Biology, Howard Hughes Medical Institute, Stanford University, Stanford, California, United States of America.
Kerri A SpilkerDepartment of Biology, Howard Hughes Medical Institute, Stanford University, Stanford, California, United States of America.
Madina S TugizovaDepartment of Biology, Howard Hughes Medical Institute, Stanford University, Stanford, California, United States of America.
Kang ShenDepartment of Biology, Howard Hughes Medical Institute, Stanford University, Stanford, California, United States of America.
Stanford University · USHoward Hughes Medical Institute · US

Funding

Howard Hughes Medical Institute
6 · The paper itself

Abstract

Forming the proper number of synapses is crucial for normal neuronal development. We found that loss of function of the phosphoinositide phosphatase mtm-6 results in a reduction in the number of synaptic puncta. The reduction in synapses is partially the result of MTM-6 regulation of the secretion of the Wnt ligand EGL-20 from cells in the tail and partially the result of neuronal action. MTM-6 shows relative specificity for EGL-20 over the other Wnt ligands. We suggest that the ability of MTM-6 to regulate EGL-20 secretion is a function of its expression pattern. We conclude that regulation of secretion of different Wnt ligands can use different components. Additionally, we present a novel neuronal function for MTM-6.

Indexed as

AnimalsCaenorhabditis elegansCaenorhabditis elegans ProteinsGlycoproteinsPhosphoric Monoester HydrolasesProtein Tyrosine Phosphatases, Non-ReceptorSynapsesWnt ProteinsCaenorhabditis elegans ProteinsEgl-20 protein, C elegansGlycoproteinsMTM-6 protein, C elegansPhosphoric Monoester HydrolasesProtein Tyrosine Phosphatases, Non-ReceptorWnt Proteins

Identifiers

PMID25479419
PMCPMC4257696
OpenAlexW2005048958

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.