ArticleeLife2014
Mapping the dynamics of force transduction at cell-cell junctions of epithelial clusters.
Article in eLife, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 75 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
75 citing papers in PubMed, 131 citations in OpenAlex.
- Guidance for 3D traction force microscopy today and in the next decade.Nature methods · 2026Review
- The application of experimental models for the drug discovery for digestive tumors.Molecular cancer · 2026Review
- Morphological and transcriptomic change of brain pericytes by lipopolysaccharide treatment.Frontiers in neural circuits · 2026Article
- From 2D to 3D and beyond: the evolution and impact of in vitro tumor models in cancer research.Nature methods · 2025Review
- Epigenetic regulation and mechanobiological adaptation in tenocytes during maturation.APL bioengineering · 2025Article
- Inferring active and passive mechanical drivers of epithelial convergent extension.bioRxiv : the preprint server for biology · 2025Article
- An Open-source Python Tool for Traction Force Microscopy on Micropatterned Substrates.Bio-protocol · 2025Article
- Myosin II tension sensors visualize force generation within the actin cytoskeleton in living cells.Journal of cell science · 2024Article
- Mechanical state transitions in the regulation of tissue form and function.Nature reviews. Molecular cell biology · 2024Review
- Field Guide to Traction Force Microscopy.Cellular and molecular bioengineering · 2024Review
- Mechanical Constraints in Tumor Guide Emergent Spatial Patterns of Glioblastoma Cancer Stem Cells.Mechanobiology in medicine · 2024Article
- A paintbrush for delivery of nanoparticles and molecules to live cells with precise spatiotemporal control.Nature methods · 2024Article
- Force propagation between epithelial cells depends on active coupling and mechano-structural polarization.eLife · 2023Article
- Inference of long-range cell-cell force transmission from ECM remodeling fluctuations.Communications biology · 2023Article
- Multicellular aligned bands disrupt global collective cell behavior.Acta biomaterialia · 2023Article
- Engineering tools for quantifying and manipulating forces in epithelia.Biophysics reviews · 2023Review
- High- and Super-Resolution Imaging of Cell-Cell Interfaces.Methods in molecular biology (Clifton, N.J.) · 2023Article
- The nonlinear motion of cells subject to external forces.Soft matter · 2022Article
- Intrinsic cell rheology drives junction maturation.Nature communications · 2022Article
- Quantifying force transmission through fibroblasts: changes of traction forces under external shearing.European biophysics journal : EBJ · 2022Article
15 more citing papers are in PubMed but not listed here.
Corrections and comments
- Erratum issued
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Force transduction at cell–cell adhesions regulates tissue development, maintenance and adaptation. We developed computational and experimental approaches to quantify, with both sub-cellular and multi-cellular resolution, the dynamics of force transmission in cell clusters. Applying this technology to spontaneously-forming adherent epithelial cell clusters, we found that basal force fluctuations were coupled to E-cadherin localization at the level of individual cell–cell junctions. At the multi-cellular scale, cell–cell force exchange depended on the cell position within a cluster, and was adaptive to reconfigurations due to cell divisions or positional rearrangements. Importantly, force transmission through a cell required coordinated modulation of cell-matrix adhesion and actomyosin contractility in the cell and its neighbors. These data provide insights into mechanisms that could control mechanical stress homeostasis in dynamic epithelial tissues, and highlight our methods as a resource for the study of mechanotransduction in cell–cell adhesions [corrected].
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.