ArticlePloS one2014
Associations between vascular health indices and serum total, free and bioavailable 25-hydroxyvitamin D in adolescents.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.
- Vitamin D status and blood pressure in children and adolescents: a systematic review of observational studies.Systematic reviews · 2021Pooled it
- Trial
- Serum 24,25-dihydroxyvitamin D level in general Korean population and its relationship with other vitamin D biomarkers.PloS one · 2021Article
- Article
- Cord Blood Vitamin D Levels and Early Childhood Blood Pressure: The Healthy Start Study.Journal of the American Heart Association · 2019Article
- Clinical Usefulness of Bioavailable Vitamin D and Impact ofInternational journal of endocrinology · 2019Article
- Total and Free 25-Hydroxy-Vitamin D and Bacterial Vaginosis in Pregnant African American Women.Infectious diseases in obstetrics and gynecology · 2019Article
- Vitamin D3 supplementation in obese, African-American, vitamin D deficient adolescents.Journal of clinical & translational endocrinology · 2018Article
- Vitamin D metabolites in captivity? Should we measure free or total 25(OH)D to assess vitamin D status?The Journal of steroid biochemistry and molecular biology · 2017Review
- Discrepant association of serum C-3 epimer of 25-hydroxyvitamin D versus non-epimeric 25-hydroxyvitamin D with serum lipid levels.Lipids in health and disease · 2016Article
- Free 25-Hydroxyvitamin D: Impact of Vitamin D Binding Protein Assays on Racial-Genotypic Associations.The Journal of clinical endocrinology and metabolism · 2016Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveThe role of vitamin D in cardiovascular health remains debated as results have been inconsistent. Previous studies have not considered the bioavailability of 25-hydroxy vitamin D [25(OH)D]. Objectives of our study were to investigate the association between serum concentrations of total, free and bioavailable 25(OH)D and independent predictors of cardiovascular risk such as flow mediated dilatation (FMD) and augmentation index (AIx).
designThis cross-sectional study included 47 post-menarchal, adolescent females [31 African American (AA) and 16 European American (EA)].
methodsAIx was standardized to a heart rate of 75 beats/min (AIx75). Free and bioavailable 25(OH)D concentrations were calculated from standard formulas. RESULTS AND
conclusionsMean age of the participants was 15.8 ± 1.4 years and mean body mass index was 23.1 ± 4.0 kg/m2. Serum total 25(OH)D was not associated with FMD, but was positively associated with AIx75 in the adjusted model (rho = 0.4, P = 0.03). AIx75 was positively associated with bioavailable 25(OH)D (rho = 0.4, P = 0.004) and free 25(OH)D (rho = 0.4, P = 0.009) and the associations persisted after adjusting for covariates. In race-specific analyses, total, free and bioavailable 25(OH)D were strongly positively associated with AIx75 in AA (rho = 0.5, 0.4, 0.4, respectively), which persisted even after adjusting for covariates. Whereas in EA there was an inverse association between total 25(OH)D and AIx75 in EA (rho = -0.6), which attenuated after adjusting for covariates.
conclusionCirculating total, free and bioavailable 25(OH)D were associated with arterial stiffness in adolescent girls, and these associations were race dependent. Notwithstanding, the implications of associations between vascular function indices and 25(OH)D remains unclear.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.