ArticleBiomacromolecules2015
Enhanced Schwann cell attachment and alignment using one-pot "dual click" GRGDS and YIGSR derivatized nanofibers.
Article in Biomacromolecules, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 52 citations in OpenAlex.
- Peptide concentration gradients and aligned microfiber topography synergize to speed and direct Schwann cell migration.Acta biomaterialia · 2026Article
- Enhanced integrin-mediated adhesion and proliferation of Schwann cells using highly aligned, dual-functional fibrous scaffolds.npj soft matter · 2026Article
- Sex-based differences in cell migration on aligned topographies.Scientific reports · 2025Article
- Review of Gaps in the Clinical Indications and Use of Neural Conduits and Artificial Grafts for Nerve Repair and Reconstruction.Biomacromolecules · 2025Review
- Mass Spectrometry Imaging of Biomaterials.Materials (Basel, Switzerland) · 2023Review
- αGlia · 2021Article
- Electrospun Fiber Scaffolds for Engineering Glial Cell Behavior to Promote Neural Regeneration.Bioengineering (Basel, Switzerland) · 2020Review
- A Comprehensive Review of the Covalent Immobilization of Biomolecules onto Electrospun Nanofibers.Nanomaterials (Basel, Switzerland) · 2020Review
- Smart ECM-Based Electrospun Biomaterials for Skeletal Muscle Regeneration.Nanomaterials (Basel, Switzerland) · 2020Review
- Postfabrication Tethering of Molecular Gradients on Aligned Nanofibers of Functional Poly(ε-caprolactone)s.Biomacromolecules · 2019Article
- Enhancing Schwann cell migration using concentration gradients of laminin-derived peptides.Biomaterials · 2019Article
- RGD-Modified Nanofibers Enhance Outcomes in Rats after Sciatic Nerve Injury.Journal of functional biomaterials · 2019Article
- RGD-Functionalized Nanofibers Increase Early GFAP Expression during Neural Differentiation of Mouse Embryonic Stem Cells.Biomacromolecules · 2019Article
- Accelerated neural differentiation of mouse embryonic stem cells on aligned GYIGSR-functionalized nanofibers.Acta biomaterialia · 2018Article
- A suspended carbon fiber culture to model myelination by human Schwann cells.Journal of materials science. Materials in medicine · 2017Article
- The Effect of Electrospun Gelatin Fibers Alignment on Schwann Cell and Axon Behavior and Organization in the Perspective of Artificial Nerve Design.International journal of molecular sciences · 2015Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Using metal-free click chemistry and oxime condensation methodologies, GRGDS and YIGSR peptides were coupled to random and aligned degradable nanofiber networks postelectrospinning in a one-pot reaction. The bound peptides are bioactive, as demonstrated by Schwann cell attachment and proliferation, and the inclusion of YIGSR with GRGDS alters the expression of the receptor for YIGSR. Additionally, aligned nanofibers act as a potential guidance cue by increasing the aspect ratio and aligning the actin filaments, which suggest that peptide-functionalized scaffolds would be useful to direct SCs for peripheral nerve regeneration.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.