ArticleLife (Basel, Switzerland)2014
Growth and division in a dynamic protocell model.
Article in Life (Basel, Switzerland), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Protocellular energy transduction, information and fitness.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2025Article
- Models of Protocells Undergoing Asymmetrical Division.Entropy (Basel, Switzerland) · 2024Article
- Multistable Protocells Can Aid the Evolution of Prebiotic Autocatalytic Sets.Life (Basel, Switzerland) · 2023Article
- The limits of metabolic heredity in protocells.Proceedings. Biological sciences · 2022Article
- Formation of Polarized, Functional Artificial Cells from Compartmentalized Droplet Networks and Nanomaterials, Using One-Step, Dual-Material 3D-Printed Microfluidics.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2020Article
- Sustainable Growth and Synchronization in Protocell Models.Life (Basel, Switzerland) · 2019Article
- Population Dynamics of Autocatalytic Sets in a Compartmentalized Spatial World.Life (Basel, Switzerland) · 2018Article
- Synthetic transitions: towards a new synthesis.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2016Review
- Generating minimal living systems from non-living materials and increasing their evolutionary abilities.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2016Review
- Emergent chemical behavior in variable-volume protocells.Life (Basel, Switzerland) · 2015Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In this paper a new model of growing and dividing protocells is described, whose main features are (i) a lipid container that grows according to the composition of the molecular milieu (ii) a set of "genetic memory molecules" (GMMs) that undergo catalytic reactions in the internal aqueous phase and (iii) a set of stochastic kinetic equations for the GMMs. The mass exchange between the external environment and the internal phase is described by simulating a semipermeable membrane and a flow driven by the differences in chemical potentials, thereby avoiding to resort to sometimes misleading simplifications, e.g., that of a flow reactor. Under simple assumptions, it is shown that synchronization takes place between the rate of replication of the GMMs and that of the container, provided that the set of reactions hosts a so-called RAF (Reflexive Autocatalytic, Food-generated) set whose influence on synchronization is hereafter discussed. It is also shown that a slight modification of the basic model that takes into account a rate-limiting term, makes possible the growth of novelties, allowing in such a way suitable evolution: so the model represents an effective basis for understanding the main abstract properties of populations of protocells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.