ArticleInternational journal of molecular sciences2014
Prenatal exposure to arsenic and cadmium impacts infectious disease-related genes within the glucocorticoid receptor signal transduction pathway.
Article in International journal of molecular sciences, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 29 citations in OpenAlex.
- Associations of exposure to blood heavy metal mixtures withFrontiers in public health · 2024Article
- Cytokine signature clusters as a tool to compare changes associated with tobacco product use in upper and lower airway samples.American journal of physiology. Lung cellular and molecular physiology · 2022Article
- Predictive modeling of biological responses in the rat liver usingComputational toxicology (Amsterdam, Netherlands) · 2021Article
- Psychosocial status modifies the effect of maternal blood metal and metalloid concentrations on birth outcomes.Environment international · 2021Article
- Arsenic exposure increased expression of HOTAIR and LincRNA-p21 in vivo and vitro.Environmental science and pollution research international · 2021Article
- Lipid Metabolism Alterations in a Rat Model of Chronic and Intergenerational Exposure to Arsenic.BioMed research international · 2019Article
- Heavy metal contamination of prenatal vitamins.Toxicology reports · 2018Article
- Evaluation of epigenetic alterations (mir-126 and mir-155 expression levels) in Mexican children exposed to inorganic arsenic via drinking water.Environmental science and pollution research international · 2017Article
- Arsenic Exposure and Type 2 Diabetes: MicroRNAs as Mechanistic Links?Current diabetes reports · 2017Review
- Effects of prenatal exposure to endocrine disruptors and toxic metals on the fetal epigenome.Epigenomics · 2017Review
- Analysis of bladder cancer tumor CpG methylation and gene expression within The Cancer Genome Atlas identifiesAmerican journal of cancer research · 2017Article
- The Association of Arsenic Exposure and Metabolism With Type 1 and Type 2 Diabetes in Youth: The SEARCH Case-Control Study.Diabetes care · 2017Article
- miRNAs as common regulators of the transforming growth factor (TGF)-β pathway in the preeclamptic placenta and cadmium-treated trophoblasts: Links between the environment, the epigenome and preeclampsia.Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association · 2016Article
- Elevated blood lead and cadmium levels associated with chronic infections among non-smokers in a cross-sectional analysis of NHANES data.Environmental health : a global access science source · 2016Article
- A cross-study analysis of prenatal exposures to environmental contaminants and the epigenome: support for stress-responsive transcription factor occupancy as a mediator of gene-specific CpG methylation patterning.Environmental epigenetics · 2016Article
- Using exposomics to assess cumulative risks and promote health.Environmental and molecular mutagenesis · 2015Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
There is increasing evidence that environmental agents mediate susceptibility to infectious disease. Studies support the impact of prenatal/early life exposure to the environmental metals inorganic arsenic (iAs) and cadmium (Cd) on increased risk for susceptibility to infection. The specific biological mechanisms that underlie such exposure-mediated effects remain understudied. This research aimed to identify key genes/signal transduction pathways that associate prenatal exposure to these toxic metals with changes in infectious disease susceptibility using a Comparative Genomic Enrichment Method (CGEM). Using CGEM an infectious disease gene (IDG) database was developed comprising 1085 genes with known roles in viral, bacterial, and parasitic disease pathways. Subsequently, datasets collected from human pregnancy cohorts exposed to iAs or Cd were examined in relationship to the IDGs, specifically focusing on data representing epigenetic modifications (5-methyl cytosine), genomic perturbations (mRNA expression), and proteomic shifts (protein expression). A set of 82 infection and exposure-related genes was identified and found to be enriched for their role in the glucocorticoid receptor signal transduction pathway. Given their common identification across numerous human cohorts and their known toxicological role in disease, the identified genes within the glucocorticoid signal transduction pathway may underlie altered infectious disease susceptibility associated with prenatal exposures to the toxic metals iAs and Cd in humans.
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Registered trials
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