Evidence map›Paper›PMID 25479050›Full record

Trial reportJournal of affective disorders2015

Augmenting psychoeducation with a mobile intervention for bipolar disorder: a randomized controlled trial.

Colin A Depp, Jenni Ceglowski, Vicki C Wang, Faraz Yaghouti, Brent T Mausbach, Wesley K Thompson, Eric L Granholm

Registry-linked trialOpen access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of affective disorders, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07239778 (The PEDAL Intervention - Reducing Affective Lability in Bipolar Disorder - a Randomised Controlled Trial), which is not on this map. Cited by 87 papers, 12 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
87citing papers in PubMed, 12 pooled it
11.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07239778 phase2not yet recruitingnot on this mapstarted 2025, after this paper: background citation

The PEDAL Intervention - Reducing Affective Lability in Bipolar Disorder - a Randomised Controlled Trial

TypeinterventionalSponsorOslo University HospitalRan2025 to 2026Enrolled120ConditionsBipolar Disorder (BD)ArmsTraditional group psychoeducation for bipolar disorder, Group psychoeducation with digital elements and focus on affective lability
3 · Its place in the literature

Who cites it

87 citing papers in PubMed, 12 syntheses or guidelines pooled it, 220 citations in OpenAlex.

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27 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Colin A DeppDepartment of Psychiatry, University of California, San Diego, CA, USA; VA San Diego Healthcare System, USA. Electronic address: cdepp@ucsd.edu.
Jenni CeglowskiDepartment of Psychiatry, University of California, San Diego, CA, USA.
Vicki C WangDepartment of Psychiatry, University of California, San Diego, CA, USA.
Faraz YaghoutiDepartment of Psychiatry, University of California, San Diego, CA, USA.
Brent T MausbachDepartment of Psychiatry, University of California, San Diego, CA, USA.
Wesley K ThompsonDepartment of Psychiatry, University of California, San Diego, CA, USA.
Eric L GranholmDepartment of Psychiatry, University of California, San Diego, CA, USA; VA San Diego Healthcare System, USA.
University of California, San Diego · USVA San Diego Healthcare System · US

Funding

Real-Time Mobile Cognitive Behavioral Intervention for Serious Mental IllnessR01MH100417 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DEPP, COLIN A. · 2013 to 2016
$2.1M
Development of a Personalized Real-Time Intervention for Bipolar DisorderR34MH091260 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DEPP, COLIN A. · 2010 to 2012
$691k
NIMH NIH HHS R01 MH100417NIMH NIH HHS R34 MH091260
6 · The paper itself

Abstract

backgroundPsychosocial interventions for bipolar disorder are frequently unavailable and resource intensive. Mobile technology may improve access to evidence-based interventions and may increase their efficacy. We evaluated the feasibility, acceptability and efficacy of an augmentative mobile ecological momentary intervention targeting self-management of mood symptoms.

methodsThis was a randomized single-blind controlled trial with 82 consumers diagnosed with bipolar disorder who completed a four-session psychoeducational intervention and were assigned to 10 weeks of either: 1) mobile device delivered interactive intervention linking patient-reported mood states with personalized self-management strategies, or 2) paper-and-pencil mood monitoring. Participants were assessed at baseline, 6 weeks (mid-point), 12 weeks (post-treatment), and 24 weeks (follow up) with clinician-rated depression and mania scales and self-reported functioning.

resultsRetention at 12 weeks was 93% and both conditions were associated with high satisfaction. Compared to the paper-and-pencil condition, participants in the augmented mobile intervention condition showed significantly greater reductions in depressive symptoms at 6 and 12 weeks (Cohen׳s d for both were d=0.48). However, these effects were not maintained at 24-weeks follow up. Conditions did not differ significantly in the impact on manic symptoms or functional impairment. LIMITATIONS: This was not a definitive trial and was not powered to detect moderators and mediators.

conclusionsAutomated mobile-phone intervention is feasible, acceptable, and may enhance the impact of brief psychoeducation on depressive symptoms in bipolar disorder. However, sustainment of gains from symptom self-management mobile interventions, once stopped, may be limited.

Indexed as

AffectCell PhoneSelf CareAdultBipolar DisorderDepressionFeasibility StudiesFemaleFollow-Up StudiesHumansMaleMiddle AgedMonitoring, AmbulatoryPatient Education as TopicSingle-Blind MethodTime FactorsBipolar disorderDepressionEcological momentary assessmentInternet-based treatmentsPsychotherapyTechnology

Identifiers

PMID25479050
PMCPMC4339469
OpenAlexW2016953118

What OpenQuestion holds

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Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.