Evidence map›Paper›PMID 25479020›Full record

Trial reportNeuroImage2015

Representation of pitch chroma by multi-peak spectral tuning in human auditory cortex.

Michelle Moerel, Federico De Martino, Roberta Santoro, Essa Yacoub, Elia Formisano

Abstract readRandomized Controlled Trial
In one paragraph

Trial report in NeuroImage, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. Article
  3. Dynamics of Pitch Perception in the Auditory Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Article
  4. Temporally Dissociable Neural Representations of Pitch Height and Chroma.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Michelle MoerelDepartment of Radiology, Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, MN 55455, USA. Electronic address: mlmoerel@umn.edu.
Federico De MartinoFaculty of Psychology and Neuroscience, Department of Cognitive Neuroscience, Maastricht University, Maastricht, 6200 MD, the Netherlands; Maastricht Brain Imaging Center (MBIC), Maastricht University, Maastricht, 6229 EV, the Netherlands.
Roberta SantoroFaculty of Psychology and Neuroscience, Department of Cognitive Neuroscience, Maastricht University, Maastricht, 6200 MD, the Netherlands; Maastricht Brain Imaging Center (MBIC), Maastricht University, Maastricht, 6229 EV, the Netherlands.
Essa YacoubDepartment of Radiology, Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, MN 55455, USA.
Elia FormisanoFaculty of Psychology and Neuroscience, Department of Cognitive Neuroscience, Maastricht University, Maastricht, 6200 MD, the Netherlands; Maastricht Brain Imaging Center (MBIC), Maastricht University, Maastricht, 6229 EV, the Netherlands.

Funding

NMR Imaging and SpectroscopyP41EB015894 · NIBIB · UNIVERSITY OF MINNESOTA · PI UGURBIL, KAMIL · 2012 to 2017
$8.4M
Institutional Center Cores for Advanced NeuroimagingP30NS076408 · NINDS · UNIVERSITY OF MINNESOTA · PI UGURBIL, KAMIL · 2012 to 2020
$4.2M
MULTICHANNEL TRANSMIT FRONTEND FOR 7 TESLAS10RR026783 · NCRR · UNIVERSITY OF MINNESOTA · PI UGURBIL, KAMIL · 2009 to 2009
$500k
NCRR NIH HHS S10 RR026783NCRR NIH HHS S10 RR26783NIBIB NIH HHS P41 EB015894NINDS NIH HHS P30 NS076408
6 · The paper itself

Abstract

Musical notes played at octave intervals (i.e., having the same pitch chroma) are perceived as similar. This well-known perceptual phenomenon lays at the foundation of melody recognition and music perception, yet its neural underpinnings remain largely unknown to date. Using fMRI with high sensitivity and spatial resolution, we examined the contribution of multi-peak spectral tuning to the neural representation of pitch chroma in human auditory cortex in two experiments. In experiment 1, our estimation of population spectral tuning curves from the responses to natural sounds confirmed--with new data--our recent results on the existence of cortical ensemble responses finely tuned to multiple frequencies at one octave distance (Moerel et al., 2013). In experiment 2, we fitted a mathematical model consisting of a pitch chroma and height component to explain the measured fMRI responses to piano notes. This analysis revealed that the octave-tuned populations-but not other cortical populations-harbored a neural representation of musical notes according to their pitch chroma. These results indicate that responses of auditory cortical populations selectively tuned to multiple frequencies at one octave distance predict well the perceptual similarity of musical notes with the same chroma, beyond the physical (frequency) distance of notes.

Indexed as

MusicAcoustic StimulationAdultAuditory CortexBrain MappingFemaleHumansMaleNerve NetPitch DiscriminationfMRI encodingHigh field functional MRIHuman auditory cortexMusicOctave perceptPitch chroma

Identifiers

PMID25479020
PMCPMC4388253

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.