Evidence map›Paper›PMID 25479016›Full record

ArticlePloS one2014

Cardiac mass and function decrease in bronchiolitis obliterans syndrome after lung transplantation: relationship to physical activity?

Jan B Hinrichs, Julius Renne, Christian Schoenfeld, Marcel Gutberlet, Axel Haverich, Gregor Warnecke, Tobias Welte, Frank Wacker, Jens Gottlieb, Jens Vogel-Claussen

Erratum issuedOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Jan B HinrichsHanover Medical School, Institute for Diagnostic and Interventional Radiology, Research in Endstage and Obstructive Lung Disease Hannover (BREATH), Member of the German Center for Lung Research, Integrated Research and Treatment Center Transplantation (IFB-Tx), Hannover, Germany.
Julius RenneHanover Medical School, Institute for Diagnostic and Interventional Radiology, Research in Endstage and Obstructive Lung Disease Hannover (BREATH), Member of the German Center for Lung Research, Integrated Research and Treatment Center Transplantation (IFB-Tx), Hannover, Germany.
Christian SchoenfeldHanover Medical School, Institute for Diagnostic and Interventional Radiology, Research in Endstage and Obstructive Lung Disease Hannover (BREATH), Member of the German Center for Lung Research, Integrated Research and Treatment Center Transplantation (IFB-Tx), Hannover, Germany.
Marcel GutberletHanover Medical School, Institute for Diagnostic and Interventional Radiology, Research in Endstage and Obstructive Lung Disease Hannover (BREATH), Member of the German Center for Lung Research, Integrated Research and Treatment Center Transplantation (IFB-Tx), Hannover, Germany.
Axel HaverichHannover Medical School, Clinic for Cardiothoracic, Transplant and Vascular Surgery, Research in Endstage and Obstructive Lung Disease Hannover (BREATH), Member of the German Center for Lung Research, Integrated Research and Treatment Center Transplantation (IFB-Tx), Hannover, Germany.
Gregor WarneckeHannover Medical School, Clinic for Cardiothoracic, Transplant and Vascular Surgery, Research in Endstage and Obstructive Lung Disease Hannover (BREATH), Member of the German Center for Lung Research, Integrated Research and Treatment Center Transplantation (IFB-Tx), Hannover, Germany.
Tobias WelteHannover Medical School, Clinic for Pneumology, Research in Endstage and Obstructive Lung Disease Hannover (BREATH), Member of the German Center for Lung Research, Integrated Research and Treatment Center Transplantation (IFB-Tx), Hannover, Germany.
Frank WackerHanover Medical School, Institute for Diagnostic and Interventional Radiology, Research in Endstage and Obstructive Lung Disease Hannover (BREATH), Member of the German Center for Lung Research, Integrated Research and Treatment Center Transplantation (IFB-Tx), Hannover, Germany.
Jens GottliebHannover Medical School, Clinic for Pneumology, Research in Endstage and Obstructive Lung Disease Hannover (BREATH), Member of the German Center for Lung Research, Integrated Research and Treatment Center Transplantation (IFB-Tx), Hannover, Germany.
Jens Vogel-ClaussenHanover Medical School, Institute for Diagnostic and Interventional Radiology, Research in Endstage and Obstructive Lung Disease Hannover (BREATH), Member of the German Center for Lung Research, Integrated Research and Treatment Center Transplantation (IFB-Tx), Hannover, Germany.
German Center for Lung Research · DEMedizinische Hochschule Hannover · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

rationaleThere is a need to expand knowledge on cardio-pulmonary pathophysiology of bronchiolitis obliterans syndrome (BOS) following lung transplantation (LTx).

objectivesThe purpose of this study was to assess MRI-derived biventricular cardiac mass and function parameters as well as flow hemodynamics in patients with and without BOS after LTx.

methodsUsing 1.5T cardiac MRI, measurements of myocardial structure and function as well as measurements of flow in the main pulmonary artery and ascending aorta were performed in 56 lung transplant patients. The patients were dichotomized into two gender matched groups of comparable age range: one with BOS (BOS stages 1-3) and one without BOS (BOS 0/0p). MEASUREMENTS AND MAIN

resultsSignificantly lower biventricular cardiac mass, right and left ventricular end-diastolic volume, biventricular stroke volume, flow hemodynamics and significant higher heart rate but preserved cardiac output were observed in patients with BOS 1-3 compared to the BOS 0/0p group (p < 0.05). In a stepwise logistic regression analysis global cardiac mass (p = 0.046) and days after LTx (p = 0.0001) remained independent parameters to predict BOS. In a second model an indicator for the physical fitness level - walking number of stairs - was added to the logistic regression model. In this second model, time after LTx (p = 0.005) and physical fitness (p = 0.01) remained independent predictors for BOS.

conclusionThe observed changes in biventricular cardiac mass and function as well as changes in hemodynamic flow parameters in the pulmonary trunk and ascending aorta are likely attributed to the physical fitness level of patients after lung transplantation, which in turn is strongly related to lung function.

Indexed as

Magnetic Resonance ImagingPhysical FitnessAdultAortographyBronchiolitis ObliteransExerciseFemaleHemodynamicsHumansLung TransplantationMaleMiddle AgedStroke Volume

Identifiers

PMID25479016
PMCPMC4257554
OpenAlexW2007339423

What OpenQuestion holds

Textmetadata
LicenceCC0
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.