ArticlePloS one2014
Hyperplasia of pericytes is one of the main characteristics of microvascular architecture in malignant glioma.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 39 citations in OpenAlex.
- Pericytes change function depending on glioblastoma vicinity: emphasis on immune regulation.Molecular oncology · 2025Article
- Pericytes in the Development and Progression of Brain Diseases.Aging and disease · 2025Review
- Glioblastoma induced blood-brain barrier dysfunction via a paracrine mechanism that increases claudin-1 expression.Experimental brain research · 2025Article
- Comparison of the Behavior of Perivascular Cells (Pericytes and CD34+ Stromal Cell/Telocytes) in Sprouting and Intussusceptive Angiogenesis.International journal of molecular sciences · 2022Review
- Review
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- Neural crest cell-derived pericytes act as pro-angiogenic cells in human neocortex development and gliomas.Fluids and barriers of the CNS · 2021Review
- Morphological and immunophenotypic characterization of perivascular interstitial cells in human glioma: Telocytes, pericytes, and mixed immunophenotypes.Oncotarget · 2020Article
- The role of deubiquitinating enzymes in gastric cancer.Oncology letters · 2020Review
- Impacts on Histological Features andTranslational oncology · 2019Article
- Microvascularity detection and quantification in glioma: a novel deep-learning-based framework.Laboratory investigation; a journal of technical methods and pathology · 2019Article
- Isocitrate dehydrogenase1 mutation reduces the pericyte coverage of microvessels in astrocytic tumours.Journal of neuro-oncology · 2019Article
- Combinatorial tissue engineering partially restores function after spinal cord injury.Journal of tissue engineering and regenerative medicine · 2019Article
- Endothelial trans-differentiation in glioblastoma recurring after radiotherapy.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2018Article
- Assessment of Micro-vessel Density in Brain Gliomaby CD105 Expression.Iranian journal of pathology · 2018Article
- CECR1-mediated cross talk between macrophages and vascular mural cells promotes neovascularization in malignant glioma.Oncogene · 2017Article
- Blood-brain barrier pericyte importance in malignant gliomas: what we can learn from stroke and Alzheimer's disease.Neuro-oncology · 2017Review
- Evaluation of rat C6 malignant glioma using spectral computed tomography.Experimental and therapeutic medicine · 2017Article
- The pathological structure of the perivascular niche in different microvascular patterns of glioblastoma.PloS one · 2017Article
- Glioma vessel abnormality quantification using time-of-flight MR angiography.Magma (New York, N.Y.) · 2016Article
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo investigate the role of pericytes in constructing the malformed microvessels (MVs) and participating microvascular architecture heterogeneity of glioma.
methodsForty human glioma tissue samples (WHO grade II-IV) were included in present study. Observation of blood vessel patterns, quantitative analysis of endothelial cells (ECs)- and pericyte-labeled MVs and comparison between malignant grades based on single- or double-immunohistochemical staining. The MV number density (MVND), microvascular pericyte number density (MPND), and microvascular pericyte area density (MPAD) were calculated. The expression of PDGFβ was also scored after immunostaining.
resultsIn grade II glioma, most of tumor MVs were the thin-wall CD34+ vessels with near normal morphology. In addition to thin-wall CD34+ MVs, more thick-wall MVs were found in grade III glioma, which often showed α-SMA positive. Most of MVs in grade IV glioma were in the form of plexus, curled cell cords and glomeruloid microvascular proliferation while the α-SMA+ cells were the main components. The MVs usually showed disordered arrangement, loose connection and active cell proliferation as shown by Ki67 and α-SMA coexpression. With the increase of glioma grades, the α-SMA+ MVND, CD34+ MVND and MPND were significantly augmented although the increase of CD34+ MVND but not MPAD was statistically insignificant between grade III and IV. It was interesting that some vessel-like structures only consist of α-SMA+ cells, assuming the guiding role of pericytes in angiogenesis. The expression level of PDGFβ was upregulated and directly correlated with the MPND in different glioma grades.
conclusionHyperplasia of pericytes was one of the significant characteristics of malignant glioma and locally proliferated pericytes were the main constituent of MVs in high grade glioma. The pathological characteristics of pericytes could be used as indexes of malignant grades of glioma.
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