ArticleThe Journal of clinical endocrinology and metabolism2015
Exposure to maternal gestational diabetes is associated with higher cardiovascular responses to stress in adolescent indians.
Article in The Journal of clinical endocrinology and metabolism, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.
- Gestational Diabetes Mellitus Among Asians - A Systematic Review From a Population Health Perspective.Frontiers in endocrinology · 2022Pooled it
- Prenatal factors shaping adolescent cardiovascular function and cardiometabolic risk trajectories.Frontiers in pediatrics · 2026Review
- Ophthalmic Changes in the Offspring of Pregnant Women with Gestational Diabetes Mellitus or Diabetes Mellitus - A Systematic Review.Clinical ophthalmology (Auckland, N.Z.) · 2025Review
- Hyperglycaemia in pregnancy and offspring blood pressure: a systematic review and meta-analysis.Diabetology & metabolic syndrome · 2023Review
- Long-term outcomes and potential mechanisms of offspring exposed to intrauterine hyperglycemia.Frontiers in nutrition · 2023Review
- Proteomics and bioinformatics analysis of cardiovascular related proteins in offspring exposed to gestational diabetes mellitus.Frontiers in cardiovascular medicine · 2022Article
- Article
- The Role of HIV Infection in the Pathophysiology of Gestational Diabetes Mellitus and Hypertensive Disorders of Pregnancy.Frontiers in cardiovascular medicine · 2021Review
- Serum Metabolites as an Indicator of Developing Gestational Diabetes Mellitus Later in the Pregnancy: A Prospective Cohort of a Chinese Population.Journal of diabetes research · 2021Article
- Maternal diabetes during pregnancy and early onset of cardiovascular disease in offspring: population based cohort study with 40 years of follow-up.BMJ (Clinical research ed.) · 2019Observational
- Maternal Nutrition and Offspring Stress Response-Implications for Future Development of Non-Communicable Disease: A Perspective From India.Frontiers in psychiatry · 2019Review
- Life course programming of stress responses in adolescents and young adults in India: Protocol of the Stress Responses in Adolescence and Vulnerability to Adult Non-communicable disease (SRAVANA) Study.Wellcome open research · 2018Article
- Maternal lipids in pregnancy are associated with increased offspring cortisol reactivity in childhood.Psychoneuroendocrinology · 2017Article
- Developmental origins of diabetes-an Indian perspective.European journal of clinical nutrition · 2017Review
- Salivary cortisol and α-amylase: subclinical indicators of stress as cardiometabolic risk.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2017Review
- Metabolic Profile of Offspring of Mothers with Gestational Diabetes Mellitus.Indian journal of endocrinology and metabolismArticle
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
Abstract
contextAltered endocrinal and autonomic nervous system responses to stress may link impaired intra-uterine growth with later cardiovascular disease.
objectiveTo test the hypothesis that offspring of gestational diabetic mothers (OGDM) have high cortisol and cardiosympathetic responses during the Trier Social Stress Test for Children (TSST-C).
designAdolescents from a birth cohort in India (n = 213; mean age, 13.5 y), including 26 OGDM, 22 offspring of diabetic fathers (ODF), and 165 offspring of nondiabetic parents (controls) completed 5 minutes each of public speaking and mental arithmetic tasks in front of two unfamiliar "evaluators" (TSST-C). Salivary cortisol concentrations were measured at baseline and at regular intervals after the TSST-C. Heart rate, blood pressure (BP), stroke volume, cardiac output, and total peripheral resistance were measured continuously at baseline, during the TSST-C, and for 10 minutes after the test using a finger cuff; the beat-to-beat values were averaged for these periods.
resultsCortisol and cardiosympathetic parameters increased from baseline during stress (P < .001). OGDM had greater systolic BP (mean difference, 5.6 mm Hg), cardiac output (0.5 L/min), and stroke volume (4.0 mL) increases and a lower total peripheral resistance rise (125 dyn · s/cm(5)) than controls during stress. ODF had greater systolic BP responses than controls (difference, 4.1 mm Hg); there was no difference in other cardiosympathetic parameters. Cortisol responses were similar in all three groups.
conclusionsMaternal diabetes during pregnancy is associated with higher cardiosympathetic stress responses in the offspring, which may contribute to their higher cardiovascular disease risk. Further research may confirm stress-response programming as a predictor of cardiovascular risk in OGDM.
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