ArticleIET systems biology2014
A technique for determining the signs of sensitivities of steady states in chemical reaction networks.
Article in IET systems biology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Ceramide-transfer protein-mediated ceramide transfer is a structurally tunable flow-inducing mechanism with structural feed-forward loops.Royal Society open science · 2018Article
- Computing the structural influence matrix for biological systems.Journal of mathematical biology · 2016Article
- Quantification of Interactions between Dynamic Cellular Network Functionalities by Cascaded Layering.PLoS computational biology · 2015Article
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1 author.
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Abstract
This paper studies the direction of change of steady states to parameter perturbations in chemical reaction networks, and, in particular, to changes in conserved quantities. Theoretical considerations lead to the formulation of a computational procedure that provides a set of possible signs of such sensitivities. The procedure is purely algebraic and combinatorial, only using information on stoichiometry, and is independent of the values of kinetic constants. Three examples of important intracellular signal transduction models are worked out as an illustration. In these examples, the set of signs found is minimal, but there is no general guarantee that the set found will always be minimal in other examples. The paper also briefly discusses the relationship of the sign problem to the question of uniqueness of steady states in stoichiometry classes.
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