ArticleJournal of clinical and diagnostic research : JCDR2014
Estimation of levels of salivary mucin, amylase and total protein in gingivitis and chronic periodontitis patients.
Article in Journal of clinical and diagnostic research : JCDR, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 73 citations in OpenAlex.
- Hydrogel Bead-Based Assay for the Measurement of Protein Biomarkers in Saliva.ACS measurement science au · 2026Article
- An in vitro study exploring the role of mucin in the protein-flavor binding mechanism.NPJ science of food · 2025Article
- Microbial functional pathways based on metatranscriptomic profiling enable effective saliva-based health assessments for precision wellness.Computational and structural biotechnology journal · 2024Article
- Exploring Salivary Alpha-Amylase as a Biomarker in Periodontitis: A Comparative Analysis of Disease Stages and Clinical Correlations.Current issues in molecular biology · 2024Article
- Variability of salivary analytes under daily conditions and their implications for periodontitis biomarkers.Frontiers in dental medicine · 2024Article
- Article
- High-Throughput Sequencing Analysis of the Changes in the Salivary Microbiota of Hungarian Young and Adult Subpopulation by an Anthocyanin Chewing Gum and Toothbrush Change.Dentistry journal · 2023Article
- Serological and Uterine Biomarkers for Detecting Endometritis in Mares.Animals : an open access journal from MDPI · 2023Article
- Evaluation of Salivary Biochemistry in Dogs with and without Plaque, Calculus, and Gingivitis: Preliminary Results.Animals : an open access journal from MDPI · 2022Article
- Supplementation With Phytogenic Compounds Modulates Salivation and Salivary Physico-Chemical Composition in Cattle Fed a High-Concentrate Diet.Frontiers in physiology · 2021Article
- Correlations between the properties of saliva and metabolic syndrome: A prospective observational study.Medicine · 2020Observational
- Article
- Oral interactions between a green tea flavanol extract and red wine anthocyanin extract using a new cell-based model: insights on the effect of different oral epithelia.Scientific reports · 2020Article
- Periodontal disease, peri-implant disease and levels of salivary biomarkers IL-1β, IL-10, RANK, OPG, MMP-2, TGF-β and TNF-α: follow-up over 5 years.Journal of applied oral science : revista FOB · 2019Article
- Article
- Analytical ultracentrifugation in saliva research: Impact of green tea astringency and its significance on the in-vivo aroma release.Scientific reports · 2018Article
- Using thermodynamic parameters to calibrate a mechanistic dose-response for infection of a host by a virus.Microbial risk analysis · 2018Article
- Salivary pH, calcium, phosphorus and selected enzymes in healthy dogs: a pilot study.BMC veterinary research · 2017Article
- Mannheimia haemolytica biofilm formation on bovine respiratory epithelial cells.Veterinary microbiology · 2016Article
- Labial Salivary Glands in Infants: Histochemical Analysis of Cytoskeletal and Antimicrobial Proteins.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2016Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPeriodontal diseases are a group of inflammatory conditions resulting from interaction between a pathogenic bacterial biofilm and susceptible host's inflammatory response eventually leading to the destruction of periodontal structures and subsequent tooth loss. Hence, investigation of salivary proteins in individuals with periodontal diseases may be useful to enhance the knowledge of their roles in these diseases. MATERIALS AND
methodsThis case-control study was conducted at A.B. Shetty Memorial Institute of Dental Sciences, Mangalore. The study comprised of 90 patients of age between 25-60 years who were clinically examined and divided into three groups of 30 each: namely clinically healthy, gingivitis and chronic periodontitis. These were classified according to the values of gingival index score, clinical attachment loss and probing pocket depth. Unstimulated saliva was collected and salivary mucin, amylase and total protein levels were determined. STATISTICAL ANALYSIS: RESULTS obtained were tabulated and statistically analyzed using ANOVA test and Karl pearson's correlation test.
resultsThe results of the study showed an increased concentration of salivary mucin, amylase and total protein in gingivitis patients and increased levels of amylase and total protein in saliva of chronic periodontitis patients compared to healthy individuals which were statistically significant. A decrease in mucin concentration was observed in the periodontitis group compared to gingivitis group. A positive correlation was present between salivary mucin, amylase and total protein levels in the three groups.
conclusionSalivary mucin, amylase and total protein may serve as an important biochemical parameter of inflammation of the periodontium. Also, it can be hypothesized that various enzyme inhibitors might be useful as a part of host modulation therapy in the treatment of periodontal diseases.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.