Evidence map›Paper›PMID 25478252›Full record

ArticleCase reports in hematology2014

A rare presentation of in situ mantle cell lymphoma and follicular lymphoma: a case report and review of the literature.

Josephine Taverna, Anju Nair, Seongseok Yun, Spencer Paulson, Jonathan H Schatz, Daniel Persky, Deborah Fuchs, Soham Puvvada

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Case reports in hematology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Josephine TavernaDivision of Hematology and Oncology, Department of Medicine, University of Arizona Cancer Center, University of Arizona, USA.ORCID 0000-0002-9191-9412
Anju NairDepartment of Medicine, University of Arizona, USA.
Seongseok YunDepartment of Medicine, University of Arizona, USA.ORCID 0000-0001-7343-1635
Spencer PaulsonDepartment of Pathology, University of Arizona, USA.
Jonathan H SchatzDivision of Hematology and Oncology, Department of Medicine, University of Arizona Cancer Center, University of Arizona, USA.
Daniel PerskyDivision of Hematology and Oncology, Department of Medicine, University of Arizona Cancer Center, University of Arizona, USA.
Deborah FuchsDepartment of Pathology, University of Arizona, USA.
Soham PuvvadaDivision of Hematology and Oncology, Department of Medicine, University of Arizona Cancer Center, University of Arizona, USA.

Funding

Cancer Prevention and Control Translational ResearchR25CA078447 · NCI · UNIVERSITY OF ARIZONA · PI ALBERTS, DAVID SAMUEL · 1998 to 2014
$7.6M
NCI NIH HHS R25 CA078447
6 · The paper itself

Abstract

A 65-year-old gentleman presented with left groin swelling over the course of two months. Physical exam revealed nontender left inguinal adenopathy, and computed tomography scans detected multiple lymph nodes in the mesenteric, aortocaval, and right common iliac regions. An excisional lymph node biopsy was performed. Pathologic evaluation demonstrated follicular center site which stained positive for PAX5, CD20, CD10, Bcl-2, Bcl-6, and mantle zone cells. These findings demonstrated CCND1 and CD5 positivity, suggesting composite lymphoma comprising follicular lymphoma (FL) with in situ mantle cell lymphoma (MCLIS). FL is known as indolent non-Hodgkin lymphoma; however, the clinical significance of a coexisting MCLIS continues to be elusive, and optimal management of these patients remains largely unknown. This case illustrates the diagnostic and therapeutic challenges of composite lymphomas. This paper also discusses advances in molecular pathogenesis and lymphoma genomics which offer novel insights into these rare diseases.

Identifiers

PMID25478252
PMCPMC4249607

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.