Evidence map›Paper›PMID 25478165›Full record

ArticleJournal of materials chemistry. B2014

Covalent layer-by-layer assembly of hyperbranched polymers on alginate microcapsulesto impart stability and permselectivity.

Km Gattás-Asfura, M Valdes, E Celik, Cl Stabler

Abstract read
In one paragraph

Article in Journal of materials chemistry. B, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Article
  3. Islet cell encapsulation - Application in diabetes treatment.Experimental biology and medicine (Maywood, N.J.) · 2021
    Review
  4. Review
  5. Article
  6. Article
  7. Bioencapsulation technologies in tissue engineering.Journal of applied biomaterials & functional materials · 2016
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Km Gattás-AsfuraDiabetes Research Institute, University of Miami, Miami, FL 33136 USA.
M ValdesDiabetes Research Institute, University of Miami, Miami, FL 33136 USA ; Department of Biomedical Engineering, University of Miami, Coral Gables, FL 33146 USA.
E CelikDepartment of Mechanical and Aerospace Engineering, University of Miami, Coral Gables, FL 33146 USA.
Cl StablerDiabetes Research Institute, University of Miami, Miami, FL 33136 USA ; Department of Biomedical Engineering, University of Miami, Coral Gables, FL 33146 USA ; Department of Surgery and Department of Biochemistry and Molecular Biology, Miller School of Medicine, University of Miami, Miami, FL 33136 USA.

Funding

Engineering Ultrathin Immunomodulatory Coatings for Islet EncapsulationR01DK100654 · NIDDK · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI STABLER, CHERIE L · 2014 to 2018
$2.2M
NIDDK NIH HHS R01 DK100654
6 · The paper itself

Abstract

The microencapsulation of cells has shown promise as a therapeutic vehicle for the treatment of a wide variety of diseases. While alginate microcapsules provide an ideal cell encapsulation material, polycations coatings are commonly employed to enhance stability and impart permselectivity. In this study, functionalized hyperbranched alginate and dendrimer polymers were used to generate discreet nanoscale coatings onto alginate microbeads via covalent layer-by-layer assembly. The bioorthogonal Staudinger ligation scheme was used to chemoselectively crosslink azide functionalized hyperbranched alginate (alginate-hN

Indexed as

dendrimerdiabetesencapsulationStaudinger ligation

Identifiers

PMID25478165
PMCPMC4249696

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.