ArticleAlzheimer's research & therapy2014
Subcortical hyperintensity volumetrics in Alzheimer's disease and normal elderly in the Sunnybrook Dementia Study: correlations with atrophy, executive function, mental processing speed, and verbal memory.
Article in Alzheimer's research & therapy, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 52 citations in OpenAlex.
- Safety, tolerability, pharmacokinetics, and pharmacodynamics of low dose lysergic acid diethylamide (LSD) in healthy older volunteers.Psychopharmacology · 2020Trial
- Clinical dementia severity associated with ventricular size is differentially moderated by cognitive reserve in men and women.Alzheimer's research & therapy · 2018Trial
- MRS demonstrates elevated brain glutathione in vascular mild cognitive impairment compared to cognitively normal coronary artery disease controls.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- The relationship between cortical thickness and white matter hyperintensities in mid to late life.Neurobiology of aging · 2024Article
- White matter hyperintensities and smaller cortical thickness are associated with neuropsychiatric symptoms in neurodegenerative and cerebrovascular diseases.Alzheimer's research & therapy · 2023Article
- Investigating the contribution of white matter hyperintensities and cortical thickness to empathy in neurodegenerative and cerebrovascular diseases.GeroScience · 2022Article
- Neuropsychiatric symptoms as a sign of small vessel disease progression in cognitive impairment.Cerebral circulation - cognition and behavior · 2022Article
- Early-stage differentiation between Alzheimer's disease and frontotemporal lobe degeneration: Clinical, neuropsychology, and neuroimaging features.Frontiers in aging neuroscience · 2022Article
- Cerebral Small Vessel Disease in Sporadic and Familial Alzheimer Disease.The American journal of pathology · 2021Review
- White matter hyperintensities in autopsy-confirmed frontotemporal lobar degeneration and Alzheimer's disease.Alzheimer's research & therapy · 2021Article
- Machine-learning method for localization of cerebral white matter hyperintensities in healthy adults based on retinal images.Brain communications · 2021Article
- Effects of White Matter Hyperintensities on Verbal Fluency in Healthy Older Adults and MCI/AD.Frontiers in aging neuroscience · 2021Article
- Brain atrophy trajectories predict differential functional performance in Alzheimer's disease: Moderations with apolipoprotein E and sex.Alzheimer's & dementia (Amsterdam, Netherlands) · 2021Article
- White Matter Microstructural Damage Associated With Gait Abnormalities in Idiopathic Normal Pressure Hydrocephalus.Frontiers in aging neuroscience · 2021Article
- Patterns of white matter hyperintensities associated with cognition in middle-aged cognitively healthy individuals.Brain imaging and behavior · 2020Article
- White matter hyperintensities mediate gray matter volume and processing speed relationship in cognitively unimpaired participants.Human brain mapping · 2020Article
- Preventing dementia by preventing stroke: The Berlin Manifesto.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2019Review
- Reaction Time and Visible White Matter Lesions in Subcortical Ischemic Vascular Cognitive Impairment.Journal of Alzheimer's disease : JAD · 2019Article
- Subcortical Ischemic Vascular Cognitive Impairment: Insights from Reaction Time Measures.Journal of Alzheimer's disease : JAD · 2019Article
- Frontal Anatomical Correlates of Cognitive and Speech Motor Deficits in Amyotrophic Lateral Sclerosis.Behavioural neurology · 2019Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionSubcortical hyperintensities (SHs) are radiological entities commonly observed on magnetic resonance imaging (MRI) of patients with Alzheimer's disease (AD) and normal elderly controls. Although the presence of SH is believed to indicate some form of subcortical vasculopathy, pathological heterogeneity, methodological differences, and the contribution of brain atrophy associated with AD pathology have yielded inconsistent results in the literature.
methodsUsing the Lesion Explorer (LE) MRI processing pipeline for SH quantification and brain atrophy, this study examined SH volumes of interest and cognitive function in a sample of patients with AD (n = 265) and normal elderly controls (n = 100) from the Sunnybrook Dementia Study.
resultsCompared with healthy controls, patients with AD were found to have less gray matter, less white matter, and more sulcal and ventricular cerebrospinal fluid (all significant, P <0.0001). Additionally, patients with AD had greater volumes of whole-brain SH (P <0.01), periventricular SH (pvSH) (P <0.01), deep white SH (dwSH) (P <0.05), and lacunar lesions (P <0.0001). In patients with AD, regression analyses revealed a significant association between global atrophy and pvSH (P = 0.02) and ventricular atrophy with whole-brain SH (P <0.0001). Regional volumes of interest revealed significant correlations with medial middle frontal SH volume and executive function (P <0.001) in normal controls but not in patients with AD, global pvSH volume and mental processing speed (P <0.01) in patients with AD, and left temporal SH volume and memory (P <0.01) in patients with AD.
conclusionsThese brain-behavior relationships and correlations with brain atrophy suggest that subtle, yet measurable, signs of small vessel disease may have potential clinical relevance as targets for treatment in Alzheimer's dementia.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.