ArticleEvidence-based complementary and alternative medicine : eCAM2014
Antioxidant and Anti-Inflammatory Activities of Phenolic-Enriched Extracts of Smilax glabra.
Article in Evidence-based complementary and alternative medicine : eCAM, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 52 citations in OpenAlex.
- Exploring the Potential Mechanism of Smilax Glabra Roxb in Periodontitis Through Network Pharmacology and Molecular Docking.Current pharmaceutical design · 2026Article
- Advances in the chemical constituents, pharmacological activity, and clinical application ofHeliyon · 2024Review
- Effect of Smilax spp. and Phellinus linteus combination on cytotoxicity and cell proliferation of breast cancer cells.BMC complementary medicine and therapies · 2023Article
- A Comprehensive Review of Herbal Supplements Used for Persistent Symptoms Attributed to Lyme Disease.Integrative medicine (Encinitas, Calif.) · 2023Review
- Article
- Phytochemical Screening, Antioxidant and Antibacterial Properties of Extracts ofPlants (Basel, Switzerland) · 2022Article
- Tentative Identification of Phytochemicals fromPlants (Basel, Switzerland) · 2022Article
- Article
- Review
- Natural Xanthine Oxidase Inhibitor 5-Molecules (Basel, Switzerland) · 2021Article
- Article
- Antioxidant and Anti-Inflammatory Activities of Six Flavonoids fromMolecules (Basel, Switzerland) · 2020Article
- Astilbin prevents osteoarthritis development through the TLR4/MD-2 pathway.Journal of cellular and molecular medicine · 2020Article
- Transdermal Delivery Systems of Natural Products Applied to Skin Therapy and Care.Molecules (Basel, Switzerland) · 2020Review
- Astilbin-induced inhibition of the PI3K/AKT signaling pathway decelerates the progression of osteoarthritis.Experimental and therapeutic medicine · 2020Article
- Article
- Protective Effects ofFrontiers in pharmacology · 2020Article
- Study of pro-angiogenic activity of astilbin on human umbilical vein endothelial cellsRSC advances · 2019Article
- Protective roles of isoastilbin against Alzheimer's disease via Nrf2‑mediated antioxidation and anti‑apoptosis.International journal of molecular medicine · 2019Article
- Diphenyl diselenide derivatives inhibit microbial biofilm formation involved in wound infection.BMC microbiology · 2016Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Smilax glabra Roxb. has been used for a long time as both food and folk medicine. In the present study, phenolic-enriched extract of S. glabra (PEESG) was extracted with 70% ethanol and purified by HP-20 column chromatography. Its antioxidant and anti-inflammatory activities were evaluated by radical scavenging assay, reducing power determination, and lipopolysaccharide (LPS)-induced RAW264.7 cells assays, respectively. PEESG exhibited obviously scavenging capacity for DPPH and ABTS radicals, as well as significant reducing power for ferric ion. Particularly, PEESG (12.5-50 μg/mL) showed a significantly higher efficiency for scavenging ABTS than that of ascorbic acid and no significant difference with ascorbic acid for DPPH scavenging. PEESG also possessed a significant suppression effect on proinflammatory mediators production, such as nitric oxide (NO), tumor necrosis factor-α (TNF-α), and interleukin-6 (IL-6), in LPS-induced RAW264.7 cells. In addition, the main ingredients of PEESG were identified using ultrahigh pressure liquid chromatography coupled to electrospray mass spectrometry (U-HPLC-ESI-MS). Seventeen components, including 5-O-caffeoylshikimic acid, neoastilbin, astilbin, neoisoastilbin, isoastilbin, engetin and isoengeletin were identified. These findings strongly suggest the potential of PEESG as a natural antioxidant and anti-inflammatory agent.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.