Evidence map›Paper›PMID 25477908›Full record

ArticleBrazilian journal of microbiology : [publication of the Brazilian Society for Microbiology]2014

Conjugative transfer of resistance determinants among human and bovine Streptococcus agalactiae.

Tatiana Castro Abreu Pinto, Natália Silva Costa, Ana Beatriz de Almeida Corrêa, Ivi Cristina Menezes de Oliveira, Marcos Correa de Mattos, Alexandre Soares Rosado, Leslie Claude Benchetrit

Open access · hybridAbstract read
In one paragraph

Article in Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology], 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
1.9field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.

  1. Molecular epidemiology ofMicrobial genomics · 2023
    Pooled it
  2. Article
  3. Towards a holistic epidemiology ofFrontiers in bioinformatics · 2026
    Article
  4. Article
  5. Article
  6. Article
  7. Multidrug Resistance and Molecular Characterization ofFrontiers in cellular and infection microbiology · 2021
    Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Tatiana Castro Abreu PintoInstituto de Microbiologia Paulo de Góes Universidade Federal do Rio de Janeiro Rio de JaneiroRJ Brazil Instituto de Microbiologia Paulo de Góes, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
Natália Silva CostaInstituto de Microbiologia Paulo de Góes Universidade Federal do Rio de Janeiro Rio de JaneiroRJ Brazil Instituto de Microbiologia Paulo de Góes, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
Ana Beatriz de Almeida CorrêaInstituto de Microbiologia Paulo de Góes Universidade Federal do Rio de Janeiro Rio de JaneiroRJ Brazil Instituto de Microbiologia Paulo de Góes, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
Ivi Cristina Menezes de OliveiraInstituto de Microbiologia Paulo de Góes Universidade Federal do Rio de Janeiro Rio de JaneiroRJ Brazil Instituto de Microbiologia Paulo de Góes, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
Marcos Correa de MattosInstituto de Microbiologia Paulo de Góes Universidade Federal do Rio de Janeiro Rio de JaneiroRJ Brazil Instituto de Microbiologia Paulo de Góes, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
Alexandre Soares RosadoInstituto de Microbiologia Paulo de Góes Universidade Federal do Rio de Janeiro Rio de JaneiroRJ Brazil Instituto de Microbiologia Paulo de Góes, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
Leslie Claude BenchetritInstituto de Microbiologia Paulo de Góes Universidade Federal do Rio de Janeiro Rio de JaneiroRJ Brazil Instituto de Microbiologia Paulo de Góes, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
Universidade Federal do Rio de Janeiro · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Streptococcus agalactiae (GBS) is a major source of human perinatal diseases and bovine mastitis. Erythromycin (Ery) and tetracycline (Tet) are usually employed for preventing human and bovine infections although resistance to such agents has become common among GBS strains. Ery and Tet resistance genes are usually carried by conjugative transposons (CTns) belonging to the Tn916 family, but their presence and transferability among GBS strains have not been totally explored. Here we evaluated the presence of Tet resistance genes (tetM and tetO) and CTns among Ery-resistant (Ery-R) and Ery-susceptible (Ery-S) GBS strains isolated from human and bovine sources; and analyzed the ability for transferring resistance determinants between strains from both origins. Tet resistance and int-Tn genes were more common among Ery-R when compared to Ery-S isolates. Conjugative transfer of all resistance genes detected among the GBS strains included in this study (ermA, ermB, mef, tetM and tetO), in frequencies between 1.10(-7) and 9.10(-7), was possible from bovine donor strains to human recipient strain, but not the other way around. This is, to our knowledge, the first report of in vitro conjugation of Ery and Tet resistance genes among GBS strains recovered from different hosts.

Indexed as

Conjugation, GeneticGene Transfer TechniquesAnimalsAnti-Bacterial AgentsCattleDNA Transposable ElementsDrug Resistance, BacterialErythromycinHumansStreptococcal InfectionsStreptococcus agalactiaeTetracyclineAnti-Bacterial AgentsDNA Transposable ElementsErythromycinTetracyclineconjugative transposonserythromycin resistanceStreptococcus agalactiae (GBS)tetracycline resistance

Identifiers

PMID25477908
PMCPMC4204959
OpenAlexW2069623747

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.