ArticleFrontiers in plant science2014
Metabolic engineering of the moss Physcomitrella patens to produce the sesquiterpenoids patchoulol and α/β-santalene.
Article in Frontiers in plant science, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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32 citing papers in PubMed, 82 citations in OpenAlex.
- Synthetic Biology of Plants and Microbes for Agriculture, Environment, and Future Applications.Chemical reviews · 2026Review
- A Review of Bryophytes: Enzymatic and Non-Enzymatic Antioxidants as a Key for Their Pharmacological Potential and Green-Biotechnological Application.Antioxidants (Basel, Switzerland) · 2025Review
- The jojoba lipid droplet protein LDAP1 facilitates the packaging of wax esters into lipid droplets.The Plant cell · 2025Article
- Strategies, Achievements, and Potential Challenges of Plant and Microbial Chassis in the Biosynthesis of Plant Secondary Metabolites.Molecules (Basel, Switzerland) · 2024Review
- Engineering Terpene Production Pathways inMicroorganisms · 2024Article
- Biotechnologies in Perfume Manufacturing: Metabolic Engineering of Terpenoid Biosynthesis.International journal of molecular sciences · 2023Review
- Farnesyl pyrophosphate compartmentalization in the green microalga Chlamydomonas reinhardtii during heterologous (E)-α-bisabolene production.Microbial cell factories · 2022Article
- Biocompatible fluorocarbon liquid underlays forRSC advances · 2022Article
- Different adaptive patterns of wheat with different drought tolerance under drought stresses and rehydration revealed by integrated metabolomic and transcriptomic analysis.Frontiers in plant science · 2022Article
- Plant cell cultures as heterologous bio-factories for secondary metabolite production.Plant communications · 2021Review
- Synthetic biology of plant natural products: From pathway elucidation to engineered biosynthesis in plant cells.Plant communications · 2021Review
- Evolution-aided engineering of plant specialized metabolism.aBIOTECH · 2021Review
- Molecular Cloning and Functional Analysis of 1-Deoxy-D-Xylulose 5-Phosphate Reductoisomerase fromGenes · 2021Article
- Advances in biotechnological production of santalenes and santalols.Chinese herbal medicines · 2021Review
- Transcriptome analysis of twoPeerJ · 2021Article
- Matching is the Key Factor to Improve the Production of Patchoulol in the Plant Chassis ofACS omega · 2020Article
- Functional expression and characterization of cinnamic acid 4-hydroxylase from the hornwort Anthoceros agrestis in Physcomitrella patens.Plant cell reports · 2020Article
- Connecting moss lipid droplets to patchoulol biosynthesis.PloS one · 2020Article
- High-Level Patchoulol Biosynthesis inFrontiers in bioengineering and biotechnology · 2020Article
- Insights into Heterologous Biosynthesis of Arteannuin B and Artemisinin inMolecules (Basel, Switzerland) · 2019Article
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4 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
The moss Physcomitrella patens, has been genetically engineered to produce patchoulol and β-santalene, two valuable sesquiterpenoid ingredients in the fragrance industry. The highest yield of patchoulol achieved was 1.34 mg/g dry weight. This was achieved by non-targeted transformation of the patchoulol synthase and either a yeast or P. patens HMGR gene under the control of a 35S promoter. Santalene synthase targeted to the plastids yielded 0.039 mg/g dry weight of α/β santalene; cytosolic santalene synthase and 35S controlled HMGR afforded 0.022 mg/g dry weight. It has been observed that the final yield of the fragrance molecules is dependent on the expression of the synthase. This is the first report of heterologous production of sesquiterpenes in moss and it opens up a promising source for light-driven production of valuable fragrance ingredients.
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