ArticleFrontiers in microbiology2014
A chemical ecogenomics approach to understand the roles of secondary metabolites in fungal cereal pathogens.
Article in Frontiers in microbiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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14 citing papers in PubMed, 37 citations in OpenAlex.
- Functional Characterization of Two Adjacent Oxygenase Genes,Journal of fungi (Basel, Switzerland) · 2026Article
- Heterologous expression of anChemical science · 2025Article
- Draft genome sequencing and secretome profiling of Sclerotinia sclerotiorum revealed effector repertoire diversity and allied broad-host range necrotrophy.Scientific reports · 2022Article
- Bioactive Metabolite Production in the GenusToxins · 2022Review
- Comparative Genomics Analyses of Lifestyle Transitions at the Origin of an Invasive Fungal Pathogen in the GenusmSphere · 2020Article
- Melleins-Intriguing Natural Compounds.Biomolecules · 2020Review
- A detailed in silico analysis of secondary metabolite biosynthesis clusters in the genome of the broad host range plant pathogenic fungus Sclerotinia sclerotiorum.BMC genomics · 2020Article
- Acquisition and Loss of Secondary Metabolites Shaped the Evolutionary Path of Three Emerging Phytopathogens of Wheat.Genome biology and evolution · 2019Article
- Heterologous biosynthesis of elsinochrome A sheds light on the formation of the photosensitive perylenequinone system.Chemical science · 2019Article
- Bipolenins K-N: New sesquiterpenoids from the fungal plant pathogenBeilstein journal of organic chemistry · 2019Article
- Accessing Nature's diversity through metabolic engineering and synthetic biology.F1000Research · 2016Review
- SnPKS19 Encodes the Polyketide Synthase for Alternariol Mycotoxin Biosynthesis in the Wheat Pathogen Parastagonospora nodorum.Applied and environmental microbiology · 2015Article
- Secondary metabolites in fungus-plant interactions.Frontiers in plant science · 2015Review
- Next-generation sequencing approach for connecting secondary metabolites to biosynthetic gene clusters in fungi.Frontiers in microbiology · 2014Review
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Secondary metabolites (SMs) are known to play important roles in the virulence and lifestyle of fungal plant pathogens. The increasing availability of fungal pathogen genome sequences and next-generation genomic tools have allowed us to survey the SM gene cluster inventory in individual fungi. Thus, there is immense opportunity for SM discovery in these plant pathogens. Comparative genomics and transcriptomics have been employed to obtain insights on the genetic features that enable fungal pathogens to adapt in individual ecological niches and to adopt the different pathogenic lifestyles. Here, we will discuss how we can use these tools to search for ecologically important SM gene clusters in fungi, using cereal pathogens as models. This ecological genomics approach, combined with genome mining and chemical ecology tools, is likely to advance our understanding of the natural functions of SMs and accelerate bioactive molecule discovery.
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