ReviewFrontiers in neurology2014
Cochlear damage affects neurotransmitter chemistry in the central auditory system.
Review in Frontiers in neurology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
13 citing papers in PubMed, 33 citations in OpenAlex.
- An MR spectroscopy study of temporal areas excluding primary auditory cortex and frontal regions in subjective bilateral and unilateral tinnitus.Scientific reports · 2023Article
- Effects of Taurine Depletion on Body Weight and Mouse Behavior during Development.Metabolites · 2022Article
- Effectiveness of bimodal auditory and electrical stimulation in patients with tinnitus: A feasibility study.Frontiers in neuroscience · 2022Article
- Neurophysiological investigation of auditory intensity dependence in patients with Parkinson's disease.Journal of neural transmission (Vienna, Austria : 1996) · 2021Article
- Loss of Cochlear Ribbon Synapse Is a Critical Contributor to Chronic Salicylate Sodium Treatment-Induced Tinnitus without Change Hearing Threshold.Neural plasticity · 2020Article
- Loss of the Cochlear Amplifier Prestin Reduces Temporal Processing Efficacy in the Central Auditory System.Frontiers in cellular neuroscience · 2018Article
- Apoptotic mechanisms after repeated noise trauma in the mouse medial geniculate body and primary auditory cortex.Experimental brain research · 2017Article
- Auditory deprivation modifies the expression of brain-derived neurotrophic factor and tropomyosin receptor kinase B in the rat auditory cortex.Journal of otology · 2017Article
- Cochlear Impairment and Autoimmune Ear Disorder in a Patient with Breast Cancer.Audiology research · 2017Article
- Neural Hyperactivity of the Central Auditory System in Response to Peripheral Damage.Neural plasticity · 2016Review
- Current view of neurotransmitter changes underlying tinnitus.Neural regeneration research · 2015Article
- Apoptosis in the cochlear nucleus and inferior colliculus upon repeated noise exposure.Noise & healthArticle
- Time course of cell death due to acoustic overstimulation in the mouse medial geniculate body and primary auditory cortex.Noise & healthArticle
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Tinnitus, the perception of a monotonous sound not actually present in the environment, affects nearly 20% of the population of the United States. Although there has been great progress in tinnitus research over the past 25 years, the neurochemical basis of tinnitus is still poorly understood. We review current research about the effects of various types of cochlear damage on the neurotransmitter chemistry in the central auditory system and document evidence that different changes in this chemistry can underlie similar behaviorally measured tinnitus symptoms. Most available data have been obtained from rodents following cochlear damage produced by cochlear ablation, intense sound, or ototoxic drugs. Effects on neurotransmitter systems have been measured as changes in neurotransmitter level, synthesis, release, uptake, and receptors. In this review, magnitudes of changes are presented for neurotransmitter-related amino acids, acetylcholine, and serotonin. A variety of effects have been found in these studies that may be related to animal model, survival time, type and/or magnitude of cochlear damage, or methodology. The overall impression from the evidence presented is that any imbalance of neurotransmitter-related chemistry could disrupt auditory processing in such a way as to produce tinnitus.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.