ArticleFrontiers in psychiatry2014
The Cannabis Pathway to Non-Affective Psychosis may Reflect Less Neurobiological Vulnerability.
Article in Frontiers in psychiatry, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 37 citations in OpenAlex.
- Replicable subcortical alterations linked to neurological soft signs in schizophrenia spectrum disorders.Psychological medicine · 2026Article
- Mapping the Interplay Between Childhood Trauma, Substance Use, and Psychopathology in Early Psychosis: A Network Analysis Approach.Schizophrenia bulletin · 2026Article
- Using Task-fMRI to Explore the Relationship Between Lifetime Cannabis Use and Cognitive Control in Individuals With First-Episode Schizophrenia.Schizophrenia bulletin open · 2024Article
- Annual incidence of substance-induced psychoses in Scandinavia from 2000 to 2016.Psychological medicine · 2023Article
- Association between Cannabis Use Disorder and Mental Health Disorders in the Adolescent Population: A Cohort Study.European addiction research · 2023Article
- A Prospective Biopsychosocial Repeated Measures Study of Stress and Dropout from Substance Addiction Treatment.Substance abuse and rehabilitation · 2023Article
- Timing of cannabis exposure relative to prodrome and psychosis onset in a community-based first episode psychosis sample.Journal of psychiatric research · 2022Article
- Geographical variation in hospitalization for psychosis associated with cannabis use and cannabis legalization in the United States: Submit to: Psychiatry Research.Psychiatry research · 2022Article
- Eye movements in patients in early psychosis with and without a history of cannabis use.NPJ schizophrenia · 2021Article
- Substance use and symptoms of mental health disorders: a prospective cohort of patients with severe substance use disorders in Norway.Substance abuse treatment, prevention, and policy · 2021Article
- Does childhood trauma influence cognitive functioning in schizophrenia? The association of childhood trauma and cognition in schizophrenia spectrum disorders.Schizophrenia research. Cognition · 2020Article
- Psychosocial characteristics differentiate non-distressing and distressing voices in 10,346 adolescents.European child & adolescent psychiatry · 2019Article
- Early Substance Use Cessation Improves Cognition-10 Years Outcome in First-Episode Psychosis Patients.Frontiers in psychiatry · 2019Article
- Prevalence and clinical relevance of interview-assessed psychosis-risk symptoms in the young adult community.Psychological medicine · 2018Article
- Heavy cannabis use prior psychosis in schizophrenia: clinical, cognitive and neurological evidences for a new endophenotype?European archives of psychiatry and clinical neuroscience · 2017Article
- Cannabis and development of dual diagnoses: A literature review.The American journal of drug and alcohol abuse · 2017Review
- Neurological soft signs in Tunisian patients with first-episode psychosis and relation with cannabis use.Annals of general psychiatry · 2017Article
- Traditional marijuana, high-potency cannabis and synthetic cannabinoids: increasing risk for psychosis.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2016Article
- Cannabinoids and Schizophrenia: Risks and Therapeutic Potential.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2015Review
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
There is a high prevalence of cannabis use reported in non-affective psychosis. Early prospective longitudinal studies conclude that cannabis use is a risk factor for psychosis, and neurochemical studies on cannabis have suggested potential mechanisms for this effect. Recent advances in the field of neuroscience and genetics may have important implications for our understanding of this relationship. Importantly, we need to better understand the vulnerability × cannabis interaction to shed light on the mediators of cannabis as a risk factor for psychosis. Thus, the present study reviews recent literature on several variables relevant for understanding the relationship between cannabis and psychosis, including age of onset, cognition, brain functioning, family history, genetics, and neurological soft signs (NSS) in non-affective psychosis. Compared with non-using non-affective psychosis, the present review shows that there seem to be fewer stable cognitive deficits in patients with cannabis use and psychosis, in addition to fewer NSS and possibly more normalized brain functioning, indicating less neurobiological vulnerability for psychosis. There are, however, some familiar and genetic vulnerabilities present in the cannabis psychosis group, which may influence the cannabis pathway to psychosis by increasing sensitivity to cannabis. Furthermore, an earlier age of onset suggests a different pathway to psychosis in the cannabis-using patients. Two alternative vulnerability models are presented to integrate these seemingly paradoxical findings.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.