ArticleFrontiers in neuroanatomy2014
The hypothalamus and periaqueductal gray are the sources of dopamine fibers in the paraventricular nucleus of the thalamus in the rat.
Article in Frontiers in neuroanatomy, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.
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Who cites it
35 citing papers in PubMed, 1 synthesis or guideline pooled it, 69 citations in OpenAlex.
- Structural and functional organization of the midline and intralaminar nuclei of the thalamus.Frontiers in behavioral neuroscience · 2022Pooled it
- Restoration of locomotor function following stimulation of the A13 region in Parkinson's mouse models.eLife · 2025Article
- Elaborating the connections of a closed-loop forebrain circuit in the rat: Circumscribed evidence for novel topography within a cortico-striato-pallidal triple descending projection, with thalamic feedback, to the anterior lateral hypothalamic area.bioRxiv : the preprint server for biology · 2025Article
- Zona incerta: from Parkinson's disease to addiction.Frontiers in neural circuits · 2025Article
- Context-dependent activation of a social behavior brain network during learned vocal production.Brain structure & function · 2023Article
- Paraventricular Thalamus Dynamically Modulates Aversive Memory via Tuning Prefrontal Inhibitory Circuitry.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Context-dependent activation of a social behavior brain network associates with learned vocal production.Research square · 2023Article
- Convergence of monosynaptic inputs from neurons in the brainstem and forebrain on parabrachial neurons that project to the paraventricular nucleus of the thalamus.Brain structure & function · 2022Article
- The influence of the subcortex and brain stem on overeating: How advances in functional neuroimaging can be applied to expand neurobiological models to beyond the cortex.Reviews in endocrine & metabolic disorders · 2022Review
- Oxytocin Receptor-Expressing Neurons in the Paraventricular Thalamus Regulate Feeding Motivation through Excitatory Projections to the Nucleus Accumbens Core.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Phenethylamine is a substrate of monoamine oxidase B in the paraventricular thalamic nucleus.Scientific reports · 2022Article
- Circuit and neuropeptide mechanisms of the paraventricular thalamus across stages of alcohol and drug use.Neuropharmacology · 2021Review
- Functional Connectivity of the Human Paraventricular Thalamic Nucleus: Insights From High Field Functional MRI.Frontiers in integrative neuroscience · 2021Article
- The Paraventricular Nucleus of the Thalamus as an Integrating and Relay Node in the Brain Anxiety Network.Frontiers in behavioral neuroscience · 2021Review
- Current Update on Clinically Relevant Sleep Issues in Parkinson's Disease: A Narrative Review.Journal of Parkinson's disease · 2021Review
- Locus Coeruleus to Paraventricular Thalamus Projections Facilitate Emergence From Isoflurane Anesthesia in Mice.Frontiers in pharmacology · 2021Article
- The Paraventricular Thalamus as a Critical Node of Motivated BehaviorFrontiers in integrative neuroscience · 2021Article
- Expression of Heparan Sulfate Endosulfatases in the Adult Mouse Brain: Co-expression ofFrontiers in neuroanatomy · 2021Article
- The lateral hypothalamus and orexinergic transmission in the paraventricular thalamus promote the attribution of incentive salience to reward-associated cues.Psychopharmacology · 2020Article
- Distributions of hypothalamic neuron populations coexpressing tyrosine hydroxylase and the vesicular GABA transporter in the mouse.The Journal of comparative neurology · 2020Article
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The paraventricular nucleus of the thalamus (PVT) sends a very dense projection to the nucleus accumbens. This area of the striatum plays a key role in motivation and recent experimental evidence indicates that the PVT may have a similar function. It is well known that a dopaminergic projection from the ventral tegmental area (VTA) to the nucleus accumbens is a key regulator of motivation and reward-related behavior. Dopamine (DA) fibers have also been localized in the PVT but the source of these fibers in the rat has not been unequivocally identified. The present study was done to re-examine this question. Small iontophoretic injections of cholera toxin B (CTb) were made in the PVT to retrogradely label tyrosine hydroxylase (TH) neurons. Neurons that were double-labeled for TH/CTb were found scattered in DA cell groups of the hypothalamus (ventrorostral A10, A11, A13, A15 DA cell groups) and the midbrain (dorsocaudal A10 embedded in the periaqueductal gray). In contrast, double-labeled neurons were absent in the retrorubral field (A8), substantia nigra (A9) and VTA (A10) of the midbrain. We conclude that DA fibers in the PVT do not originate from VTA but from a heterogeneous population of DA neurons located in the hypothalamus and periaqueductal gray.
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