Evidence map›Paper›PMID 25477547›Full record

ArticleThe Canadian veterinary journal = La revue veterinaire canadienne2014

Inhibition of priming for bovine respiratory syncytial virus-specific protective immune responses following parenteral vaccination of passively immune calves.

John Ellis, Sheryl Gow, Michael Bolton, William Burdett, Scott Nordstrom

Open access · greenAbstract read
PubMed Full text at PMC
In one paragraph

Article in The Canadian veterinary journal = La revue veterinaire canadienne, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.

  1. Pooled it
  2. Bovine respiratory syncytial virus-specific IgG-1 in nasal secretions of colostrum-fed neonatal calves.The Canadian veterinary journal = La revue veterinaire canadienne · 2018
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

John EllisThe Departments of Veterinary Microbiology (Ellis) and Large Animal Clinical Sciences (Gow), Western College of Veterinary Medicine, University of Saskatchewan, 52 Campus Drive, Saskatoon, Saskatchewan, Canada S7N 5B4, and Merck Animal Health, Summit, New Jersey, USA (Bolton, Burdett, Nordstrom).
Sheryl GowThe Departments of Veterinary Microbiology (Ellis) and Large Animal Clinical Sciences (Gow), Western College of Veterinary Medicine, University of Saskatchewan, 52 Campus Drive, Saskatoon, Saskatchewan, Canada S7N 5B4, and Merck Animal Health, Summit, New Jersey, USA (Bolton, Burdett, Nordstrom).
Michael BoltonThe Departments of Veterinary Microbiology (Ellis) and Large Animal Clinical Sciences (Gow), Western College of Veterinary Medicine, University of Saskatchewan, 52 Campus Drive, Saskatoon, Saskatchewan, Canada S7N 5B4, and Merck Animal Health, Summit, New Jersey, USA (Bolton, Burdett, Nordstrom).
William BurdettThe Departments of Veterinary Microbiology (Ellis) and Large Animal Clinical Sciences (Gow), Western College of Veterinary Medicine, University of Saskatchewan, 52 Campus Drive, Saskatoon, Saskatchewan, Canada S7N 5B4, and Merck Animal Health, Summit, New Jersey, USA (Bolton, Burdett, Nordstrom).
Scott NordstromThe Departments of Veterinary Microbiology (Ellis) and Large Animal Clinical Sciences (Gow), Western College of Veterinary Medicine, University of Saskatchewan, 52 Campus Drive, Saskatoon, Saskatchewan, Canada S7N 5B4, and Merck Animal Health, Summit, New Jersey, USA (Bolton, Burdett, Nordstrom).
University of Saskatchewan · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The effect of maternal antibodies (MatAb) on immunological priming by neonatal parenteral vaccination for bovine respiratory syncytial virus (BRSV) was addressed for the first time in experimental infection in 34 Holstein calves. Both vaccinated and control calves developed moderate to severe respiratory disease characteristic of acute BRSV infection. There were no differences in clinical signs, BRSV shed, arterial oxygen concentrations, or mortality between vaccinated and control calves after BRSV challenge approximately 11 wk after vaccination. There were no anamnestic antibody or cytokine responses in the vaccinates after challenge. Lung lesions were extensive in both groups, and although there was a statistically significant (P = 0.05) difference between groups, this difference was considered not biologically significant. These data indicate that stimulation of protective immune responses was inhibited by maternal antibodies when a combination modified-live BRSV vaccine was administered parenterally to young passively immune calves. Alternate routes of administration or different vaccine formulations should be used to successfully immunize young calves with good passive antibody transfer.

Indexed as

AnimalsAnimals, NewbornAntibodies, ViralCattleCattle DiseasesCytokinesImmunization, PassiveInjections, SubcutaneousRespiratory Syncytial Virus, BovineRespiratory Syncytial Virus InfectionsViral VaccinesAntibodies, ViralCytokinesViral Vaccines

Identifiers

PMID25477547
PMCPMC4231808
OpenAlexW2402421668

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.