ArticleAmerican journal of physiology. Regulatory, integrative and comparative physiology2015
Role of FAT/CD36 in fatty acid sensing, energy, and glucose homeostasis regulation in DIO and DR rats.
Article in American journal of physiology. Regulatory, integrative and comparative physiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The trial behind it
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Who cites it
18 citing papers in PubMed, 33 citations in OpenAlex.
- Molecular cloning and gene/protein expression of FAT/CD36 from grass carp (Ctenopharyngodon idella) and the regulation of its expression by dietary energy.Fish physiology and biochemistry · 2017Trial
- Prohibitions in the meta-inflammatory response: a review.Frontiers in molecular biosciences · 2024Review
- β-Hydroxybutyrate preferentially enhances neuron over astrocyte respiration while signaling cellular quiescence.Mitochondrion · 2023Article
- CD36 Senses Dietary Lipids and Regulates Lipids Homeostasis in the Intestine.Frontiers in physiology · 2021Review
- Housing Temperature Modulates the Impact of Diet-Induced Rise in Fat Mass on Adipose Tissue Before and During Pregnancy in Rats.Frontiers in physiology · 2019Article
- Transcriptomic responses of hypothalamus to acute exercise in type 2 diabetic Goto-Kakizaki rats.PeerJ · 2019Article
- Hypothalamic Fatty Acids and Ketone Bodies Sensing and Role of FAT/CD36 in the Regulation of Food Intake.Frontiers in physiology · 2019Review
- Neuroketotherapeutics: A modern review of a century-old therapy.Neurochemistry international · 2018Review
- The CD36-PPARγ Pathway in Metabolic Disorders.International journal of molecular sciences · 2018Review
- Amylin Selectively Signals Onto POMC Neurons in the Arcuate Nucleus of the Hypothalamus.Diabetes · 2018Article
- Effect of developmental NMDAR antagonism with CGP 39551 on aspartame-induced hypothalamic and adrenal gene expression.PloS one · 2018Article
- Highlight report: Import of fatty acids by metastasizing tumor cells.EXCLI journal · 2018Article
- Involvement of CD36 in Modulating the Decrease of NPY and AgRP Induced by Acute Palmitic Acid Stimulation in N1E-115 Cells.Nutrients · 2017Article
- Nutrient Sensing: Another Chemosensitivity of the Olfactory System.Frontiers in physiology · 2017Review
- Hypothalamic sensing of ketone bodies after prolonged cerebral exposure leads to metabolic control dysregulation.Scientific reports · 2016Article
- Fatty acid-induced astrocyte ketone production and the control of food intake.American journal of physiology. Regulatory, integrative and comparative physiology · 2016Review
- Dietary Lipids Inform the Gut and Brain about Meal Arrival via CD36-Mediated Signal Transduction.The Journal of nutrition · 2015Review
- Role of VMH ketone bodies in adjusting caloric intake to increased dietary fat content in DIO and DR rats.American journal of physiology. Regulatory, integrative and comparative physiology · 2015Article
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 1 country.
Funding
Abstract
Hypothalamic fatty acid (FA) sensing neurons alter their activity utilizing the FA translocator/receptor, FAT/CD36. Depletion of ventromedial hypothalamus (VMH) CD36 with adeno-associated viral vector expressing CD36 shRNA (AAV CD36 shRNA) leads to redistribution of adipose stores and insulin resistance in outbred rats. This study assessed the requirement of VMH CD36-mediated FA sensing for the regulation of energy and glucose homeostasis in postnatal day 5 (P5) and P21 selectively bred diet-induced obese (DIO) and diet-resistant (DR) rats using VMH AAV CD36 shRNA injections. P5 CD36 depletion altered VMH neuronal FA sensing predominantly in DIO rats. After 10 wk on a 45% fat diet, DIO rats injected with VMH AAV CD36 shRNA at P21 ate more and gained more weight than DIO AAV controls, while DR AAV CD36 shRNA-injected rats gained less weight than DR AAV controls. VMH CD36 depletion increased inguinal fat pad weights and leptin levels in DIO and DR rats. Although DR AAV CD36 shRNA-injected rats became as obese as DIO AAV controls, only DIO control and CD36 depleted rats became insulin-resistant on a 45% fat diet. VMH CD36 depletion stunted linear growth in DIO and DR rats. DIO rats injected with AAV CD36 shRNA at P5 had increased fat mass, mostly due to a 45% increase in subcutaneous fat. They were also insulin-resistant with an associated 71% increase of liver triglycerides. These results demonstrate that VMH CD36-mediated FA sensing is a critical factor in the regulation of energy and glucose homeostasis and fat deposition in DIO and DR rats.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.