Evidence map›Paper›PMID 25477388›Full record

ArticleNucleic acids research2015

BioAssay Research Database (BARD): chemical biology and probe-development enabled by structured metadata and result types.

E A Howe, A de Souza, D L Lahr, S Chatwin, P Montgomery, B R Alexander, D-T Nguyen, Y Cruz, D A Stonich, G Walzer and 20 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nucleic acids research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Article
  2. A Novel Fluorescence Polarization Binding Assay for the Main Protease (MACS pharmacology & translational science · 2025
    Article
  3. Article
  4. Data Mining and Computational Modeling of High-Throughput Screening Datasets.Methods in molecular biology (Clifton, N.J.) · 2018
    Article
  5. Review
  6. Review
  7. Review
  8. PubChem BioAssay: 2017 update.Nucleic acids research · 2017
    Article
  9. Article
  10. Article
  11. bioassayR: Cross-Target Analysis of Small Molecule Bioactivity.Journal of chemical information and modeling · 2016
    Article
  12. Article
  13. How to Triage PAINS-Full Research.Assay and drug development technologies · 2016
    Article
  14. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

30 authors.

E A HoweCenter for the Science of Therapeutics, Broad Institute, 415 Main Street, Cambridge, MA 02142, USA.
A de SouzaCenter for the Science of Therapeutics, Broad Institute, 415 Main Street, Cambridge, MA 02142, USA Andrea.desouza@sloan.mit.edu.
D L LahrCenter for the Science of Therapeutics, Broad Institute, 415 Main Street, Cambridge, MA 02142, USA.
S ChatwinCenter for the Science of Therapeutics, Broad Institute, 415 Main Street, Cambridge, MA 02142, USA.
P MontgomeryCenter for the Science of Therapeutics, Broad Institute, 415 Main Street, Cambridge, MA 02142, USA.ORCID http://orcid.org/0000-0002-2633-1081
B R AlexanderCenter for the Science of Therapeutics, Broad Institute, 415 Main Street, Cambridge, MA 02142, USA.
D-T NguyenNational Center for Advancing Translational Sciences (NCATS), National Institutes of Health (NIH), 9800 Medical Center Drive, Rockville, MD 20850, USA.ORCID http://orcid.org/0000-0003-2591-9948
Y CruzThe Translational Research Institute, The Scripps Research Institute, 130 Scripps Way, Jupiter, FL 33458, USA.
D A StonichConrad Prebys Center for Chemical Genomics, Sanford|Burnham Medical Research Institute, 10901 N. Torrey Pines Road, La Jolla, CA 92037, USA.
G WalzerCenter for the Science of Therapeutics, Broad Institute, 415 Main Street, Cambridge, MA 02142, USA.
J T RoseCenter for the Science of Therapeutics, Broad Institute, 415 Main Street, Cambridge, MA 02142, USA.ORCID http://orcid.org/0000-0003-1932-8391
S C PicardCenter for the Science of Therapeutics, Broad Institute, 415 Main Street, Cambridge, MA 02142, USA.ORCID http://orcid.org/0000-0003-0853-4472
Z LiuCenter for the Science of Therapeutics, Broad Institute, 415 Main Street, Cambridge, MA 02142, USA.ORCID http://orcid.org/0000-0001-7504-249X
J N RoseCenter for the Science of Therapeutics, Broad Institute, 415 Main Street, Cambridge, MA 02142, USA.ORCID http://orcid.org/0000-0001-7121-3095
X XiangCenter for the Science of Therapeutics, Broad Institute, 415 Main Street, Cambridge, MA 02142, USA.
J AsieduCenter for the Science of Therapeutics, Broad Institute, 415 Main Street, Cambridge, MA 02142, USA.
D DurkinCenter for the Science of Therapeutics, Broad Institute, 415 Main Street, Cambridge, MA 02142, USA.
J LevineCenter for the Science of Therapeutics, Broad Institute, 415 Main Street, Cambridge, MA 02142, USA.
J J YangUniversity of New Mexico Center for Molecular Discovery, University of New Mexico Health Sciences Center, 2500 Marble Avenue NE, Albuquerque, NM 87131, USA.
S C SchürerCenter for Computational Science, University of Miami, 1320 S. Dixie Highway, Gables One Tower, Coral Gables, FL 33146, USA.
J C BraistedNational Center for Advancing Translational Sciences (NCATS), National Institutes of Health (NIH), 9800 Medical Center Drive, Rockville, MD 20850, USA.
N SouthallNational Center for Advancing Translational Sciences (NCATS), National Institutes of Health (NIH), 9800 Medical Center Drive, Rockville, MD 20850, USA.
M R SouthernThe Translational Research Institute, The Scripps Research Institute, 130 Scripps Way, Jupiter, FL 33458, USA.
T D Y ChungConrad Prebys Center for Chemical Genomics, Sanford|Burnham Medical Research Institute, 10901 N. Torrey Pines Road, La Jolla, CA 92037, USA.
S BrudzCenter for the Science of Therapeutics, Broad Institute, 415 Main Street, Cambridge, MA 02142, USA.ORCID http://orcid.org/0000-0002-9394-6705
C TanegaNational Center for Advancing Translational Sciences (NCATS), National Institutes of Health (NIH), 9800 Medical Center Drive, Rockville, MD 20850, USA.
S L SchreiberCenter for the Science of Therapeutics, Broad Institute, 415 Main Street, Cambridge, MA 02142, USA.
J A BittkerCenter for the Science of Therapeutics, Broad Institute, 415 Main Street, Cambridge, MA 02142, USA.
R GuhaNational Center for Advancing Translational Sciences (NCATS), National Institutes of Health (NIH), 9800 Medical Center Drive, Rockville, MD 20850, USA guhar@mail.nih.gov.ORCID http://orcid.org/0000-0001-7403-8819
P A ClemonsCenter for the Science of Therapeutics, Broad Institute, 415 Main Street, Cambridge, MA 02142, USA pclemons@broadinstitute.org.

Funding

User Driven ProjectU54HG005032 · NHGRI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI SCHREIBER, STUART L · 2008 to 2013
$88.1M
NHGRI NIH HHS U54-HG005032
6 · The paper itself

Abstract

BARD, the BioAssay Research Database (https://bard.nih.gov/) is a public database and suite of tools developed to provide access to bioassay data produced by the NIH Molecular Libraries Program (MLP). Data from 631 MLP projects were migrated to a new structured vocabulary designed to capture bioassay data in a formalized manner, with particular emphasis placed on the description of assay protocols. New data can be submitted to BARD with a user-friendly set of tools that assist in the creation of appropriately formatted datasets and assay definitions. Data published through the BARD application program interface (API) can be accessed by researchers using web-based query tools or a desktop client. Third-party developers wishing to create new tools can use the API to produce stand-alone tools or new plug-ins that can be integrated into BARD. The entire BARD suite of tools therefore supports three classes of researcher: those who wish to publish data, those who wish to mine data for testable hypotheses, and those in the developer community who wish to build tools that leverage this carefully curated chemical biology resource.

Indexed as

Biological AssayDatabases, FactualHigh-Throughput Screening AssaysData MiningInternetMolecular ProbesSoftwareMolecular Probes

Identifiers

PMID25477388
PMCPMC4383997

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.