Evidence map›Paper›PMID 25477359›Full record

ArticleAJNR. American journal of neuroradiology2015

Imaging the intracranial atherosclerotic vessel wall using 7T MRI: initial comparison with histopathology.

A G van der Kolk, J J M Zwanenburg, N P Denswil, A Vink, W G M Spliet, M J A P Daemen, F Visser, D W J Klomp, P R Luijten, J Hendrikse

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in AJNR. American journal of neuroradiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

46 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Article
  5. Intracranial vessel wall lesions on MRI: anatomical and pathological issues.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025
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  15. UltraHigh Field MR Imaging in Epilepsy.Magnetic resonance imaging clinics of North America · 2021
    Review
  16. Review
  17. TFrontiers in neuroscience · 2021
    Article
  18. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

A G van der KolkRadiology (A.G.v.d.K., J.J.M.Z., F.V., D.W.J.K., P.R.L., J.H.) A.G.vanderKolk@umcutrecht.nl.
J J M ZwanenburgRadiology (A.G.v.d.K., J.J.M.Z., F.V., D.W.J.K., P.R.L., J.H.) Image Sciences Institute (J.J.M.Z.), University Medical Center Utrecht, Utrecht, the Netherlands.
N P DenswilDepartment of Pathology (N.P.D., M.J.A.P.D.), Academic Medical Center Amsterdam, Amsterdam, the Netherlands.
A VinkFrom the Departments of Pathology (A.V., W.G.M.S.).
W G M SplietFrom the Departments of Pathology (A.V., W.G.M.S.).
M J A P DaemenDepartment of Pathology (N.P.D., M.J.A.P.D.), Academic Medical Center Amsterdam, Amsterdam, the Netherlands.
F VisserRadiology (A.G.v.d.K., J.J.M.Z., F.V., D.W.J.K., P.R.L., J.H.) Philips Healthcare (F.V.), Best, the Netherlands.
D W J KlompRadiology (A.G.v.d.K., J.J.M.Z., F.V., D.W.J.K., P.R.L., J.H.).
P R LuijtenRadiology (A.G.v.d.K., J.J.M.Z., F.V., D.W.J.K., P.R.L., J.H.).
J HendrikseRadiology (A.G.v.d.K., J.J.M.Z., F.V., D.W.J.K., P.R.L., J.H.).

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

background and purposeSeveral studies have attempted to characterize intracranial atherosclerotic plaques by using MR imaging sequences. However, dedicated validation of these sequences with histology has not yet been performed. The current study assessed the ability of ultra-high-resolution 7T MR imaging sequences with different image contrast weightings to image plaque components, by using histology as criterion standard. MATERIALS AND

methodsFive specimens of the circle of Wills were imaged at 7T with 0.11 × 0.11 mm in-plane-resolution proton attenuation-, T1-, T2-, and T2*-weighted sequences (through-plane resolution, 0.11-1 mm). Tissue samples from 13 fiducial-marked locations (per specimen) on MR imaging underwent histologic processing and atherosclerotic plaque classification. Reconstructed MR images were matched with histologic sections at corresponding locations.

resultsForty-four samples were available for subsequent evaluation of agreement or disagreement between plaque components and image contrast differences. Of samples, 52.3% (n = 23) showed no image contrast heterogeneity; this group comprised solely no lesions or early lesions. Of samples, 25.0% (n = 11, mostly advanced lesions) showed good correlation between the spatial organization of MR imaging heterogeneities and plaque components. Areas of foamy macrophages were generally seen as proton attenuation-, T2-, and T2*- hypointense areas, while areas of increased collagen content showed more ambiguous signal intensities. Five samples showed image-contrast heterogeneity without corresponding plaque components on histology; 5 other samples showed contrast heterogeneity based on intima-media artifacts.

conclusionsMR imaging at 7T has the image contrast capable of identifying both focal intracranial vessel wall thickening and distinguishing areas of different signal intensities spatially corresponding to plaque components within more advanced atherosclerotic plaques.

Indexed as

HumansImage Processing, Computer-AssistedIntracranial ArteriosclerosisMagnetic Resonance ImagingPlaque, Atherosclerotic

Identifiers

PMID25477359
PMCPMC7964300

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.