ArticleStroke2015
Symptomatic carotid atherosclerotic disease: correlations between plaque composition and ipsilateral stroke risk.
Article in Stroke, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 66 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
66 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Artificial intelligence diagnostic performance in image-based vulnerable carotid plaque detection: a systematic review and meta-analysis.BMC medical informatics and decision making · 2025Pooled it
- A Systematic Review for the Design of In Vitro Flow Studies of the Carotid Artery Bifurcation.Cardiovascular engineering and technology · 2020Pooled it
- Diagnostic performance of MRI for detecting intraplaque hemorrhage in the carotid arteries: a meta-analysis.European radiology · 2019Pooled it
- Efficacy of acupuncture in patients with carotid atherosclerosis: a randomized controlled clinical trial.BMC complementary medicine and therapies · 2024Trial
- Identification of high-risk carotid plaque with MRI-based radiomics and machine learning.European radiology · 2021Trial
- Relation between carotid vulnerable plaques and peripheral leukocyte: a case-control study of comparison utilizing multi-parametric contrast-enhanced ultrasound.BMC medical imaging · 2019Trial
- Gene expression profiles of carotid plaques differ between patients with amaurosis fugax and those with cerebral transient ischaemic attack or stroke.Cardiovascular research · 2026Article
- Modern Management of Asymptomatic Carotid Stenosis: A Meta-Analysis of CREST-2, SPACE-2, and ECST-2.Annals of clinical and translational neurology · 2026Article
- Flexible Ultrasound Patch for Noninvasive, Targeted Anti-Angiogenic Therapy of Unstable Carotid Plaques.Annals of biomedical engineering · 2026Article
- Multimodal Radiomics Model Combining HR-VWI and Clinical Features for Identifying Symptomatic Basilar Atherosclerotic Plaques.BioMed research international · 2026Article
- Integrating untargeted metabolomics and deep learning approaches to identify specific metabolic signatures and new mechanisms in unstable plaques.Frontiers in cardiovascular medicine · 2026Article
- Post-irradiation vertebral and carotid stenosis heightens stroke risk in head and neck cancer.BMC cancer · 2025Observational
- Exploring the risk stratification of carotid plaque hemodynamic using four-dimensional blood flow technology.Frontiers in molecular biosciences · 2025Article
- Insulin resistance, vulnerable plaque and stroke risk in patients with carotid artery stenosis.Scientific reports · 2024Article
- Construction of vulnerable plaque prediction model based on multimodal vascular ultrasound parameters and clinical risk factors.Scientific reports · 2024Article
- The value of contrast-enhanced ultrasonography in predicting stroke occurrence: A prospective study.Heliyon · 2024Article
- Quantitative evaluation using carotid ultrasonography-based high-frame-rate vector flow imaging in patients with low carotid stenosis.The British journal of radiology · 2024Article
- Gray-Scale Median in Patients with Symptomatic and Asymptomatic Carotid Atherosclerosis-Risk Factors and Diagnostic Potential.Biomedicines · 2024Article
- Article
- Vascular Calcification Heterogeneity from Bench to Bedside: Implications for Manifestations, Pathogenesis, and Treatment Considerations.Aging and disease · 2024Review
6 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
background and purposeFor symptomatic patients with carotid artery stenosis, the risk benefit for surgical intervention may vary among patient groups. Various modalities of plaque imaging have been promoted as potential tools for additional risk stratification, particularly in patients with moderate stenosis. However, it remains uncertain to what extent carotid plaque components predict risk of future ipsilateral ischemic stroke.
methodsIn 2 large atherosclerotic carotid plaque biobank studies, we related histological characteristics of 1640 carotid plaques with a validated risk model for the prediction of individual 1- and 5-year stroke risk.
resultsNo significant heterogeneity between the studies was found. Predicted 5-year stroke risk (top versus bottom quartile) was related to plaque thrombus (odds ratio, 1.42; 95% confidence interval, 1.11-1.89; P=0.02), fibrous content (0.65; 0.49-0.87; P=0.004), macrophage infiltration (1.41; 1.05-1.90; P=0.02), high microvessel density (1.49; 1.05-2.11; P=0.03), and overall plaque instability (1.40; 1.05-1.87; P=0.02). This association was not observed for cap thickness, calcification, intraplaque hemorrhage, or lymphocyte infiltration. Plaques removed within 30 days of most recent symptomatic event were most strongly correlated with predicted stroke risk.
conclusionsFeatures of the vulnerable carotid plaque, including plaque thrombus, low fibrous content, macrophage infiltration, and microvessel density, correlate with predicted stroke risk. This study provides a basis for plaque imaging studies focused on stroke risk stratification.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.