Evidence map›Paper›PMID 25476872›Full record

ArticleCardiovascular and interventional radiology2015

Delayed-Phase Cone-Beam CT Improves Detectability of Intrahepatic Cholangiocarcinoma During Conventional Transarterial Chemoembolization.

Ruediger Egbert Schernthaner, MingDe Lin, Rafael Duran, Julius Chapiro, Zhijun Wang, Jean-François Geschwind

Abstract read
In one paragraph

Article in Cardiovascular and interventional radiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
2.6field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 22 citations in OpenAlex.

  1. Trial
  2. Review
  3. Article
  4. Article
  5. CIRSE Standards of Practice on Hepatic Transarterial Chemoembolisation.Cardiovascular and interventional radiology · 2021
    Article
  6. Review
  7. Review
  8. Article
  9. Observational
  10. Review
  11. Article
  12. Article
  13. Review
  14. Article
  15. Automatic bone removal for 3D TACE planning with C-arm CBCT: Evaluation of technical feasibility.Minimally invasive therapy & allied technologies : MITAT : official journal of the Society for Minimally Invasive Therapy · 2016
    Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Ruediger Egbert SchernthanerRussell H. Morgan Department of Radiology and Radiological Science, Division of Vascular and Interventional Radiology, The Johns Hopkins Hospital, Sheikh Zayed Tower, Suite 7203, 1800 Orleans St, Baltimore, MD, 21287, USA.
MingDe Lin
Rafael Duran
Julius Chapiro
Zhijun Wang
Jean-François Geschwind
Johns Hopkins Hospital · USPhilips (Finland) · FI

Funding

Translational Research Central ServicesP30CA006973 · NCI · JOHNS HOPKINS UNIVERSITY · PI Rosalie Wollett · 1985 to 2026
$208.6M
See, Reach, Treat Tumor-Optimized Transarterial Chemoembolization DrugDeliveryR01CA160771 · NCI · YALE UNIVERSITY · PI GESCHWIND, JEAN-FRANCOIS H, LIN, MINGDE · 2011 to 2015
$2.6M
NCI NIH HHS NIH/NCI R01 CA160771NCI NIH HHS P30 CA006973NCI NIH HHS P30CA006973NCI NIH HHS R01 CA160771
6 · The paper itself

Abstract

purposeTo evaluate the detectability of intrahepatic cholangiocarcinoma (ICC) on dual-phase cone-beam CT (DPCBCT) during conventional transarterial chemoembolization (cTACE) compared to that of digital subtraction angiography (DSA) with respect to pre-procedure contrast-enhanced magnetic resonance imaging (CE-MRI) of the liver.

methodsThis retrospective study included 17 consecutive patients (10 male, mean age 64) with ICC who underwent pre-procedure CE-MRI of the liver, and DSA and DPCBCT (early-arterial phase (EAP) and delayed-arterial phase (DAP)) just before cTACE. The visibility of each ICC lesion was graded by two radiologists on a three-rank scale (complete, partial, and none) on DPCBCT and DSA images, and then compared to pre-procedure CE-MRI.

resultsOf 61 ICC lesions, only 45.9% were depicted by DSA, whereas EAP- and DAP-CBCT yielded a significantly higher detectability rate of 73.8% and 93.4%, respectively (p < 0.01). Out of the 33 lesions missed on DSA, 18 (54.5%) and 30 (90.9%) were revealed on EAP- and DAP-CBCT images, respectively. DSA depicted only one lesion that was missed by DPCBCT due to streak artifacts caused by a prosthetic mitral valve. DAP-CBCT identified significantly more lesions than EAP-CBCT (p < 0.01). Conversely, EAP-CBCT did not detect lesions missed by DAP-CBCT. For complete lesion visibility, DAP-CBCT yielded significantly higher detectability (78.7%) compared to EAP (31.1%) and DSA (21.3%) (p < 0.01).

conclusionDPCBCT, and especially the DAP-CBCT, significantly improved the detectability of ICC lesions during cTACE compared to DSA. We recommend the routine use of DAP-CBCT in patients with ICC for per-procedure detectability and treatment planning in the setting of TACE.

Indexed as

Chemoembolization, TherapeuticCone-Beam Computed TomographyAngiography, Digital SubtractionBile Duct NeoplasmsCholangiocarcinomaCohort StudiesFemaleHumansLiverMagnetic Resonance ImagingMaleMiddle AgedObserver VariationRadiography, InterventionalReproducibility of ResultsRetrospective Studies

Identifiers

PMID25476872
PMCPMC4457721
OpenAlexW2077042321

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.