Evidence map›Paper›PMID 25476831›Full record

ArticleLife sciences2015

Role of caveolin-3 in lymphocyte activation.

Chinh Tran, Creed M Stary, Jan M Schilling, Brandon Bentley, Hemal H Patel, David M Roth

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Life sciences, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Chinh TranDepartment of Anesthesiology, Veterans Affairs San Diego Healthcare System, University of California, San Diego, La Jolla, CA, United States.
Creed M StaryDepartment of Anesthesia, Stanford University, Stanford, CA, United States.
Jan M SchillingDepartment of Anesthesiology, Veterans Affairs San Diego Healthcare System, University of California, San Diego, La Jolla, CA, United States.
Brandon BentleyDepartment of Anesthesiology, Veterans Affairs San Diego Healthcare System, University of California, San Diego, La Jolla, CA, United States.
Hemal H PatelDepartment of Anesthesiology, Veterans Affairs San Diego Healthcare System, University of California, San Diego, La Jolla, CA, United States.
David M RothDepartment of Anesthesiology, Veterans Affairs San Diego Healthcare System, University of California, San Diego, La Jolla, CA, United States. Electronic address: droth@ucsd.edu.
VA San Diego Healthcare System · USStanford University · USUniversity of California, San Diego · US

Funding

Vector Production CoreP01HL066941 · NHLBI · VETERANS MEDICAL RESEARCH FDN/SAN DIEGO · PI MIYANOHARA, ATSUSHI · 2001 to 2017
$34.8M
Research in Anesthesia Training Program (ReAP)T32GM089626 · NIGMS · STANFORD UNIVERSITY · PI Vivianne L Tawfik · 2010 to 2026
$5.2M
Caveolae, mitochondria, and cardiac protection.R01HL091071 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI PATEL, HEMAL H · 2008 to 2019
$3.8M
Integrins and Caveolin Proteins in Cardiac Hypertrophy and FailureR01HL115933 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ROSS, ROBERT SCOTT, ROTH, DAVID M · 2013 to 2016
$2.6M
Protection of the Aged MyocardiumR01HL107200 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI PATEL, HEMAL H, ROTH, DAVID M · 2011 to 2014
$2.1M
Modulation of Natriuretic Peptides via Caveolin in Hypertrophy and Heart Failure.I01BX000783 · VA · VA SAN DIEGO HEALTHCARE SYSTEM · PI ROTH, DAVID M · 2011 to 2019
–
Novel Therapeutics for Diabetic CardiomyopathyI01BX001963 · VA · VA SAN DIEGO HEALTHCARE SYSTEM · PI PATEL, HEMAL H · 2013 to 2025
–
BLRD VA I01 BX000783BLRD VA I01 BX001963NHLBI NIH HHS HL066941NHLBI NIH HHS HL091071NHLBI NIH HHS HL107200NHLBI NIH HHS HL115933NHLBI NIH HHS P01 HL066941NHLBI NIH HHS R01 HL091071NHLBI NIH HHS R01 HL107200NHLBI NIH HHS R01 HL115933NIGMS NIH HHS T32 GM089626NIGMS NIH HHS T32-GM089626
6 · The paper itself

Abstract

aimsCaveolins are structural proteins clustered in lipid-rich regions of plasma membrane involved in coordinating signal transduction in various organ systems. While caveolin-1 (Cav-1) has been shown to regulate lymphocyte activation, the role of caveolin-3 (Cav-3) in immune system signaling has not been investigated. We tested the hypothesis that Cav-3 modulates lymphocyte activation. MAIN

methodsLymphocyte/leukocyte subpopulations from WT and Cav-3 mice were profiled with flow cytometry. Cytokine production in quiescent and activated splenocytes from WT and Cav-3 mice was assessed with ELISA. KEY

findingsLevels of T-cells, monocytes, and natural killer cells were not different between WT and KO mice, however KO mice had lower B-cell population-percentage. Functionally, activated lymphocytes from Cav-3 KO mice demonstrated significantly reduced expression of IL-2 compared to WT, while expression of TNFα, IL-6, and IL-10 was not different. Finally, expression of IL-17 was significantly reduced in T-helper cells from KO mice, while IFNγ was not, suggesting that Cav-3 is a determinant in the development of the Th-17 subpopulation. SIGNIFICANCE: This study is the first to demonstrate that Cav-3 may be a novel participant in B-cell expression, T-cell cytokine production and activation of inflammation.

Indexed as

AnimalsCaveolin 3CytokinesFlow CytometryHumansImmune SystemLymphocyte ActivationLymphocyte CountMiceMice, Inbred C57BLMice, KnockoutSignal TransductionCaveolin 3CytokinesCytokineImmune systemInflammationLeukocyteSignaling

Identifiers

PMID25476831
PMCPMC4410709
OpenAlexW2049158905

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.