ArticleBMC genomics2014
Epigenetic signature of birth weight discordance in adult twins.
Article in BMC genomics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 2 of them syntheses that pooled it.
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Who cites it
35 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Low birth weight as a predictor of adverse health outcomes during adulthood in twins: a systematic review and meta-analysis.Systematic reviews · 2021Pooled it
- Associations between body size, nutrition and socioeconomic position in early life and the epigenome: A systematic review.PloS one · 2018Pooled it
- Article
- Blood and adipose tissue DNA methylation in adults born preterm with a very low birth weight - a sibling comparison study.Epigenomics · 2026Article
- Twin pairs discordant for incident coronary artery disease reveal epigenetic and transcriptomic differences by gene region.Molecular genetics and genomics : MGG · 2025Article
- Epigenetic drift score captures directional methylation variability and links aging to transcriptional, metabolic, and genetic alterations.Genome research · 2025Article
- MethAgingDB: a comprehensive DNA methylation database for aging biology.Scientific data · 2025Article
- Weighted 2D-kernel density estimations provide a new probabilistic measure for epigenetic age.Genome biology · 2025Article
- The Multi-State Epigenetic Pacemaker enables the identification of combinations of factors that influence DNA methylation.GeroScience · 2025Article
- Birth weight discordance, gene expression, and DNA methylation: A scoping review of epigenetic twin studies.PloS one · 2025Article
- Developmental hematopoietic stem cell variation explains clonal hematopoiesis later in life.Nature communications · 2024Article
- Multi-omics association study of DNA methylation and gene expression levels and diagnoses of cardiovascular diseases in Danish Twins.Clinical epigenetics · 2024Article
- Article
- Identifying epigenetic aging moderators using the epigenetic pacemaker.Frontiers in bioinformatics · 2023Article
- Article
- Age patterns of intra-pair DNA methylation discordance in twins: Sex difference in epigenomic instability and implication on survival.Aging cell · 2021Article
- Ageing-associated changes in DNA methylation in X and Y chromosomes.Epigenetics & chromatin · 2021Article
- Article
- Equivalent DNA methylation variation between monozygotic co-twins and unrelated individuals reveals universal epigenetic inter-individual dissimilarity.Genome biology · 2021Article
- New targeted approaches for epigenetic age predictions.BMC biology · 2020Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundA low birth weight has been extensively related to poor adult health outcomes. Birth weight can be seen as a proxy for environmental conditions during prenatal development. Identical twin pairs discordant for birth weight provide an extraordinary model for investigating the association between birth weight and adult life health while controlling for not only genetics but also postnatal rearing environment. We performed an epigenome-wide profiling on blood samples from 150 pairs of adult monozygotic twins discordant for birth weight to look for molecular evidence of epigenetic signatures in association with birth weight discordance.
resultsOur association analysis revealed no CpG site with genome-wide statistical significance (FDR < 0.05) for either qualitative (larger or smaller) or quantitative discordance in birth weight. Even with selected samples of extremely birth weight discordant twin pairs, no significant site was found except for 3 CpGs that displayed age-dependent intra-pair differential methylation with FDRs 0.014 (cg26856578, p = 3.42e-08), 0.0256 (cg15122603, p = 1.25e-07) and 0.0258 (cg16636641, p = 2.05e-07). Among the three sites, intra-pair differential methylation increased with age for cg26856578 but decreased with age for cg15122603 and cg16636641. There was no genome-wide statistical significance for sex-dependent effects on intra-pair differential methylation in either the whole samples or the extremely discordant twins.
conclusionsGenome-wide DNA methylation profiling did not reveal epigenetic signatures of birth weight discordance although some sites displayed age-dependent intra-pair differential methylation in the extremely discordant twin pairs.
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