ArticleThe Journal of allergy and clinical immunology2015
Rhinoviruses significantly affect day-to-day respiratory symptoms of children with asthma.
Article in The Journal of allergy and clinical immunology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 2 syntheses or guidelines pooled it, 32 citations in OpenAlex.
- Prevalence of respiratory viruses in stable and acute asthma: a systematic review and meta-analysis.European respiratory review : an official journal of the European Respiratory Society · 2026Pooled it
- Systematic review of the impact of point-of-care testing for influenza on the outcomes of patients with acute respiratory tract infection.Reviews in medical virology · 2018Pooled it
- Recurrent Infections in Allergic Pediatric Patients: An Immune System Problem? A Narrative Review.Children (Basel, Switzerland) · 2025Review
- Common cold.Frontiers in allergy · 2023Review
- Viruses associated with acute respiratory infection in a community-based cohort of healthy New Zealand children.Journal of medical virology · 2022Article
- Article
- Article
- Particle sizes of infectious aerosols: implications for infection control.The Lancet. Respiratory medicine · 2020Review
- The Impact of Ambient Environmental Exposures to Microbial Products on Asthma Outcomes from Birth to Childhood.Current allergy and asthma reports · 2019Review
- Impact of community respiratory viral infections in urban children with asthma.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2019Article
- Epidemiological analysis and follow-up of human rhinovirus infection in children with asthma exacerbation.Journal of medical virology · 2018Article
- Nasopharyngeal isolates and their clinical impact on young children with asthma: a pilot study.Journal of asthma and allergy · 2018Article
- Respiratory syncytial virus infection influences tight junction integrity.Clinical and experimental immunology · 2017Article
- Dual RNA-seq reveals viral infections in asthmatic children without respiratory illness which are associated with changes in the airway transcriptome.Genome biology · 2017Article
- [Rhinovirus during childhood: Asthma at adolescence? The chicken or the egg causality dilemma].Archives de pediatrie : organe officiel de la Societe francaise de pediatrie · 2016Article
- Time-Based Measurement of Personal Mite Allergen Bioaerosol Exposure over 24 Hour Periods.PloS one · 2016Article
- Clinical, virological and epidemiological characteristics of rhinovirus infections in early childhood: A comparison between non-hospitalised and hospitalised children.Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 7 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundViruses are frequently associated with acute exacerbations of asthma, but the extent to which they contribute to the level of day-to-day symptom control is less clear.
objectiveWe sought to explore the relationship between viral infections, host and environmental factors, and respiratory symptoms in children.
methodsSixty-seven asthmatic children collected samples twice weekly for an average of 10 weeks. These included nasal wash fluid and exhaled breath for PCR-based detection of viral RNA, lung function measurements, and records of medication use and asthma and respiratory symptoms in the previous 3 days. Atopy, mite allergen exposure, and vitamin D levels were also measured. Mixed-model regression analyses were performed.
resultsHuman rhinoviruses (hRVs) were detected in 25.5% of 1232 nasal samples and 11.5% of breath samples. Non-hRV viruses were detected in less than 3% of samples. hRV in nasal samples was associated with asthma symptoms (cough and phlegm: odds ratio = 2.0; 95% CI = 1.4-2.86, P = .0001; wheeze and chest tightness: odds ratio = 2.34, 95% CI = 1.55-3.52, P < .0001) and with cold symptoms, as reported concurrently with sampling and 3 to 4 days later. No differences were found between the 3 hRV genotypes (hRV-A, hRV-B, and hRV-C) in symptom risk. A history of inhaled corticosteroid use, but not atopic status, mite allergen exposure, or vitamin D levels, modified the association between viruses and asthma symptoms.
conclusionThe detection of nasal hRV was associated with a significantly increased risk of day-to-day asthma symptoms in children. Host, virus genotype, and environmental factors each had only a small or no effect on the relationship of viral infections to asthma symptoms.
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