Evidence map›Paper›PMID 25476588›Full record

ArticleMacromolecular bioscience2015

Non-covalent photo-patterning of gelatin matrices using caged collagen mimetic peptides.

Yang Li, Boi Hoa San, Julian L Kessler, Jin Hwan Kim, Qingguo Xu, Justin Hanes, Seungju Michael Yu

Abstract read
In one paragraph

Article in Macromolecular bioscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
3.5field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 29 citations in OpenAlex.

  1. Article
  2. The Chemistry and Biology of Collagen Hybridization.Journal of the American Chemical Society · 2023
    Review
  3. Review
  4. Article
  5. Article
  6. Spatially and Temporally Controlled Hydrogels for Tissue Engineering.Materials science & engineering. R, Reports : a review journal · 2017
    Article
  7. Article
  8. Article
  9. Targeting collagen for diagnostic imaging and therapeutic delivery.Journal of controlled release : official journal of the Controlled Release Society · 2016
    Review
  10. Peptide-Based Supramolecular Hydrogels for Delivery of Biologics.Bioengineering & translational medicine · 2016
    Article
  11. Article
  12. Article
  13. Thiol-ene and photo-cleavage chemistry for controlled presentation of biomolecules in hydrogels.Journal of controlled release : official journal of the Controlled Release Society · 2015
    Review
  14. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Yang LiDepartment of Bioengineering, University of Utah, 36 S. Wasatch Drive, 3100 SMBB, Salt Lake City, Utah, 84112, USA.
Boi Hoa San
Julian L Kessler
Jin Hwan Kim
Qingguo Xu
Justin Hanes
Seungju Michael Yu
University of Utah · USJohns Hopkins University · USWasatch Molecular (United States) · US

Funding

Wilmer Core Grant for Vision ResearchP30EY001765 · NEI · JOHNS HOPKINS UNIVERSITY · PI Jiang Qian · 1985 to 2026
$22.1M
Study and Application of Collagen Mimetic Peptide-Collagen HybridizationR01AR060484 · NIAMS · UNIVERSITY OF UTAH · PI YU, MICHAEL S · 2011 to 2015
$1.7M
Collagen-Targeted Therapeutics of Cathepsin InhibitorsR21AR065124 · NIAMS · UNIVERSITY OF UTAH · PI YU, MICHAEL S · 2014 to 2015
$381k
Non-Covalent Modification of Collagen ScaffoldsR21GM074812 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI YU, MICHAEL S · 2005 to 2006
$371k
NEI NIH HHS P30 EY001765NEI NIH HHS P30EY001765NIAMS NIH HHS R01 AR060484NIAMS NIH HHS R01-AR060484NIAMS NIH HHS R21 AR065124NIAMS NIH HHS R21-AR065124NIGMS NIH HHS R21 GM074812
6 · The paper itself

Abstract

To address the downside of conventional photo-patterning which can alter the chemical composition of protein scaffolds, we developed a non-covalent photo-patterning strategy for gelatin (denatured collagen) hydrogels that utilizes UV activated triple helical hybridization of caged collagen mimetic peptide (caged CMP). Here we present 2D and 3D photo-patterning of gelatin hydrogels enabled by the caged CMP derivatives, as well as creation of concentration gradients of CMPs. CMP's specificity for binding to gelatin allows patterning of almost any synthetic or natural gelatin-containing matrix, such as gelatin-methacrylate hydrogels and corneal tissues. This is a radically new tool for immobilizing drugs to natural tissues and for functionalizing scaffolds for complex tissue formation.

Indexed as

BiomimeticsCollagenDrug Delivery SystemsGelatinHydrogelsNanomedicinePeptidesPhotochemistryProtein BindingTissue ScaffoldsCollagenGelatinHydrogelsPeptideshydrogelmicroenvironmentspatial controltissue engineeringtriple helix

Identifiers

PMID25476588
PMCPMC4430332
OpenAlexW1770086942

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.