Evidence map›Paper›PMID 25476402›Full record

ReviewMovement disorders : official journal of the Movement Disorder Society2015

Linking neuroscience with modern concepts of impulse control disorders in Parkinson's disease.

T Celeste Napier, Jean-Christophe Corvol, Anthony A Grace, Jamie D Roitman, James Rowe, Valerie Voon, Antonio P Strafella

Open access · greenAbstract readReview
In one paragraph

Review in Movement disorders : official journal of the Movement Disorder Society, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
8.8field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 93 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. Review
  5. Redefining Non-Motor Symptoms in Parkinson's Disease.Journal of personalized medicine · 2025
    Review
  6. Review
  7. Review
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Brain Imaging and Impulse Control Disorders in Parkinson's Disease.Current neurology and neuroscience reports · 2019
    Review
  16. Compulsive eating behaviors in Parkinson's disease.Eating and weight disorders : EWD · 2019
    Article
  17. Review
  18. Article
  19. Cognitive and behavioral disorders in Parkinson's disease: an update. II: behavioral disorders.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2018
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 7 institutions in 5 countries.

T Celeste NapierDepartments of Pharmacology and Psychiatry, Center for Compulsive Behavior and Addiction, Rush University Medical Center, Chicago, IL, USA.
Jean-Christophe Corvol
Anthony A Grace
Jamie D Roitman
James Rowe
Valerie Voon
Antonio P Strafella
Centre for Addiction and Mental Health · CAInserm · FRMedical Research Council · GBRush University Medical Center · USUniversity of Cambridge · GBUniversity of Illinois Chicago · USUniversity of Pittsburgh · US

Funding

Gating of Information Flow Within the Nucleus Accumbens (Supplement)R01MH057440 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI ANTHONY A GRACE · 1997 to 2026
$7.2M
USE AND DRUG DEPENDENT NEUROPROTECTION--TROPIC FACTORSP50NS019608 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI ZIGMOND, MICHAEL J · 2003 to 2009
$6.5M
Gating of Information Flow Within the Nucleus AccumbensR37MH057440 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI GRACE, ANTHONY A · 2007 to 2016
$3.3M
NEUROPLASTICITY IN DAMAGED CATECHOLAMINERGIC SYSTEMSP01NS019608 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI ZIGMOND, MICHAEL J · 1985 to 2002
$2.1M
A novel rodent model of dopamine agonist-induced impulsive control disordersR21NS074014 · NINDS · RUSH UNIVERSITY MEDICAL CENTER · PI NAPIER, T. CELESTE · 2011 to 2012
$421k
Cortico-striatal signaling in risk preferenceR21DA027127 · NIDA · UNIVERSITY OF ILLINOIS AT CHICAGO · PI ROITMAN, JAMIE D. · 2010 to 2011
$385k
Circumventing physiological consequences of drug abuseR21DA036328 · NIDA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI GRACE, ANTHONY A · 2013 to 2014
$380k
Role of D3 receptors in drug-induced impulsivity in a rat model of Parkinson's diF31DA033121 · NIDA · RUSH UNIVERSITY MEDICAL CENTER · PI TEDFORD, STEPHANIE E · 2012 to 2014
$127k
Medical Research Council G0001354Medical Research Council MC_U105597119Medical Research Council MC_US_A060_0016NIDA NIH HHS DA027127NIDA NIH HHS DA0331231NIDA NIH HHS DA036328NIDA NIH HHS F31 DA033121NIDA NIH HHS R21 DA027127NIDA NIH HHS R21 DA036328NIMH NIH HHS MH57440NIMH NIH HHS R01 MH057440NIMH NIH HHS R37 MH057440NINDS NIH HHS NS074014NINDS NIH HHS NS19608NINDS NIH HHS P01 NS019608NINDS NIH HHS R21 NS074014Wellcome TrustWellcome Trust 088324
6 · The paper itself

Abstract

Patients with Parkinson's disease (PD) may experience impulse control disorders (ICDs) when on dopamine agonist therapy for their motor symptoms. In the last few years, a rapid growth of interest for the recognition of these aberrant behaviors and their neurobiological correlates has occurred. Recent advances in neuroimaging are helping to identify the neuroanatomical networks responsible for these ICDs, and together with psychopharmacological assessments are providing new insights into the brain status of impulsive behavior. The genetic associations that may be unique to ICDs in PD are also being identified. Complementing human studies, electrophysiological and biochemical studies in animal models are providing insights into neuropathological mechanisms associated with these disorders. New animal models of ICDs in PD patients are being implemented that should provide critical means to identify efficacious therapies for PD-related motor deficits while avoiding ICD side effects. Here, we provide an overview of these recent advances, with a particular emphasis on the neurobiological correlates reported in animal models and patients along with their genetic underpinnings.

Indexed as

AnimalsBrainDisease Models, AnimalDisruptive, Impulse Control, and Conduct DisordersDopamine AgonistsHumansImpulsive BehaviorParkinson DiseaseDopamine Agonists6-OHDAbasal gangliadopamine agonistsfMRIimagingl-dopaPETpramipexoleprefrontal cortex

Identifiers

PMID25476402
PMCPMC4318759
OpenAlexW1595118030

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.