ArticleBMC genetics2014
Genetic landscape of populations along the Silk Road: admixture and migration patterns.
Article in BMC genetics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Initial Genome-Wide Characterization of Turkmen Individuals from the Dashoguz Region, Turkmenistan.Biology · 2026Article
- Genetic structure analysis of a Northwest Chinese population using a self-developed DIP system and machine learning for forensic ancestry inference.BMC genomics · 2026Article
- Largest-Scale Genomic Resource Reconstructing the Genetic Origin, Population Structure, and Biological Adaptations of the Hui People.Molecular biology and evolution · 2025Article
- Analysis of maternal genetic structure of mitochondrial DNA control region from Tai-Kadai-speaking Buyei population in southwestern China.BMC genomics · 2024Article
- Identifying missing pieces in color vision defects: a genome-wide association study in Silk Road populations.Frontiers in genetics · 2023Article
- Impact of cultural and genetic structure on food choices along the Silk Road.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Article
- Global invasion history of the agricultural pest butterflyProceedings of the National Academy of Sciences of the United States of America · 2019Article
- Cx26 partial loss causes accelerated presbycusis by redox imbalance and dysregulation of Nfr2 pathway.Redox biology · 2018Article
- Genomic admixture tracks pulses of economic activity over 2,000 years in the Indian Ocean trading network.Scientific reports · 2017Article
- Revisiting the male genetic landscape of China: a multi-center study of almost 38,000 Y-STR haplotypes.Human genetics · 2017Article
- Genetic structure in the Sherpa and neighboring Nepalese populations.BMC genomics · 2017Article
- The Complex Admixture History and Recent Southern Origins of Siberian Populations.Molecular biology and evolution · 2016Article
- Genetic evidence for an origin of the Armenians from Bronze Age mixing of multiple populations.European journal of human genetics : EJHG · 2016Article
- Global diversity in the TAS2R38 bitter taste receptor: revisiting a classic evolutionary PROPosal.Scientific reports · 2016Article
- Early modern human dispersal from Africa: genomic evidence for multiple waves of migration.Investigative genetics · 2015Article
- Genome-wide insights into the genetic history of human populations.Investigative genetics · 2015Article
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7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe ancient Silk Road has been a trading route between Europe and Central Asia from the 2(nd) century BCE to the 15(th) century CE. While most populations on this route have been characterized, the genetic background of others remains poorly understood, and little is known about past migration patterns. The scientific expedition "Marco Polo" has recently collected genetic and phenotypic data in six regions (Georgia, Armenia, Azerbaijan, Uzbekistan, Kazakhstan, Tajikistan) along the Silk Road to study the genetics of a number of phenotypes.
resultsWe characterized the genetic structure of these populations within a worldwide context. We observed a West-East subdivision albeit the existence of a genetic component shared within Central Asia and nearby populations from Europe and Near East. We observed a contribution of up to 50% from Europe and Asia to most of the populations that have been analyzed. The contribution from Asia dates back to ~25 generations and is limited to the Eastern Silk Road. Time and direction of this contribution are consistent with the Mongolian expansion era.
conclusionsWe clarified the genetic structure of six populations from Central Asia and suggested a complex pattern of gene flow among them. We provided a map of migration events in time and space and we quantified exchanges among populations. Altogether these novel findings will support the future studies aimed at understanding the genetics of the phenotypes that have been collected during the Marco Polo campaign, they will provide insights into the history of these populations, and they will be useful to reconstruct the developments and events that have shaped modern Eurasians genomes.
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