Evidence map›Paper›PMID 25476233›Full record

ReviewJournal of dermatological science2015

Bone marrow stromal cells as immunomodulators. A primer for dermatologists.

Krisztian Nemeth, Eva Mezey

Abstract readReview
In one paragraph

Review in Journal of dermatological science, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Krisztian NemethAdult Stem Cell Section, CSDB, NIDCR, National Institutes of Health, Bethesda, MD, United States. Electronic address: nemethk@mail.nih.gov.
Eva MezeyAdult Stem Cell Section, CSDB, NIDCR, National Institutes of Health, Bethesda, MD, United States.

Funding

Contribution of bone marrow cells to tissue regeneration, immune function and hematopoiesisZIADE000714 · NIDCR · NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH · PI MEZEY, EVA M. · 2009 to 2025
$25.3M
Intramural NIH HHS Z99 DE999999
6 · The paper itself

Abstract

Bone marrow stromal cells (BMSCs, also known as mesenchymal stem cells or MSCs) represent a unique cell population in the bone marrow with a long-known function to support hematopoiesis and replace skeletal tissues. The recent discovery that BMSCs also possess potent immunoregulatory features attracted a great deal of attention from stem cell biologists, immunologists and clinicians of different specialties worldwide. Initial clinical experience along with several animal models suggested that intravenously delivered BMSCs are able to regulate a wide variety of host immune cells and act in a way that is beneficial for the recipient in a variety of diseases. The role of the present review is to give a short introduction to the biology of BMSCs and to summarize our current understanding of how BMSCs modulate the immune system with special emphasis on available clinical data. Considering the audience of this journal we will also attempt to guide dermatologists in choosing the right skin conditions where BMSCs might be considered as a therapeutic alternative.

Indexed as

AnimalsBone Marrow CellsBone Marrow TransplantationDermatologyFibrosisGraft vs Host DiseaseHumansHypersensitivityImmune SystemImmunologic FactorsLiverLungMiceSkinSkin DiseasesSkin Physiological PhenomenaImmunologic FactorsBone marrow stromal cellsImmunomodulationInflammatoryMesenchymal stem cellsSkin conditions

Identifiers

PMID25476233
PMCPMC4294767

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.