ReviewAnnals of biomedical engineering2015
Scaffold-based anti-infection strategies in bone repair.
Review in Annals of biomedical engineering, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
52 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Cartilage tissue healing and regeneration based on biocompatible materials: a systematic review and bibliometric analysis from 1993 to 2022.Frontiers in pharmacology · 2023Pooled it
- Recent advances in metal-organic frameworks for the diagnosis and treatment of breast cancer.Discover nano · 2026Review
- Dual-Functional Triphasic Composite Scaffolds for Enhanced Antibacterial and Osteogenic Performance in Preventing Osteomyelitis Recurrence.ACS omega · 2026Article
- PCL/Chitosan/Bioglass Hybrid Composite Shape Memory Scaffolds With Accelerated Degradation and Enhanced Bioactivity.Macromolecular materials and engineering · 2026Article
- CaO-SiOMaterials (Basel, Switzerland) · 2026Article
- Janus Membranes as Multifunctional Nanostructures for Bone Defect Repair: Advances, Challenges, and Clinical Translation.International journal of nanomedicine · 2026Review
- Hybrid Chitosan/PCL Shape Memory Scaffolds with Potential for Bone Regeneration and Infection Resistance.ACS biomaterials science & engineering · 2025Article
- Plasma activated PVDF-BaTiOScientific reports · 2025Article
- Hyaluronic acid-based hydrogel microspheres with multi-responsive properties for antibacterial therapy and bone regeneration inMaterials today. Bio · 2025Article
- Anti-Infection Efficacy, Osteogenesis Potential, and Biocompatibility of 3D Printed PLGA/Nano-Hydroxyapatite Porous Scaffolds Grafted with Vancomycin/DOPA/rhBMP-2 in Infected Rabbit Bone Defects.International journal of nanomedicine · 2025Article
- Functionalized conductive polymer composites for tissue engineering and biomedical applications- a mini review.Frontiers in bioengineering and biotechnology · 2025Review
- Recent advances in the application of nanotechnology in joint arthroplasty: a narrative review.Annals of joint · 2025Review
- Dental pulp regeneration strategies: A review of status quo and recent advances.Bioactive materials · 2024Review
- Engineering antibacterial bioceramics: Design principles and mechanisms of action.Materials today. Bio · 2024Review
- Preparation of PDA-GO/CS composite scaffold and its effects on the biological properties of human dental pulp stem cells.BMC oral health · 2024Article
- Antimicrobial Surface for Devices Used in Stem Culture Manipulation and In Vitro Biofabrication of Tissues.Methods in molecular biology (Clifton, N.J.) · 2024Article
- A drug-loaded composite coating to improve osteogenic and antibacterial properties of Zn-1Mg porous scaffolds as biodegradable bone implants.Bioactive materials · 2023Article
- Enhancing Bone Grafting Outcomes: A Comprehensive Review of Antibacterial Artificial Composite Bone Scaffolds.Medical science monitor : international medical journal of experimental and clinical research · 2023Review
- Regenerative endodontic procedures in immature permanent teeth with pulp necrosis: the impact of microbiology on clinical and radiographic outcome.Frontiers in dental medicine · 2023Article
- LL-37-Coupled Porous Composite Scaffold for the Treatment of Infected Segmental Bone Defect.Pharmaceutics · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Bone fractures and non-union defects often require surgical intervention where biomaterials are used to correct the defect, and approximately 10% of these procedures are compromised by bacterial infection. Currently, treatment options are limited to sustained, high doses of antibiotics and surgical debridement of affected tissue, leaving a significant, unmet need for the development of therapies to combat device-associated biofilm and infections. Engineering implants to prevent infection is a desirable material characteristic. Tissue engineered scaffolds for bone repair provide a means to both regenerate bone and serve as a base for adding antimicrobial agents. Incorporating anti-infection properties into regenerative medicine therapies could improve clinical outcomes and reduce the morbidity and mortality associated with biomaterial implant-associated infections. This review focuses on current animal models and technologies available to assess bone repair in the context of infection, antimicrobial agents to fight infection, the current state of antimicrobial scaffolds, and future directions in the field.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.