ArticleJournal of pediatric surgery2014
Single-stage versus multi-stage pull-through for Hirschsprung's disease: practice trends and outcomes in infants.
Article in Journal of pediatric surgery, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 2 syntheses or guidelines pooled it, 56 citations in OpenAlex.
- Optimal timing for Soave primary pull-through in short-segment Hirschsprung disease: A meta-analysis.Journal of pediatric surgery · 2022Pooled it
- Variability of outcome reporting in Hirschsprung's Disease and gastroschisis: a systematic review.Scientific reports · 2016Pooled it
- Feasibility and efficacy of home rectal irrigation in neonates and early infancy with Hirschsprung disease.Pediatric surgery international · 2019Trial
- Comparison of Postoperative Outcomes of Duhamel and Transanal Endorectal Pull-Through in Hirschsprung Disease: A Propensity Score Study.Pediatric reports · 2026Article
- Surgical Outcomes of Acute Mastoiditis in Pediatric Patients: A Pediatric Health Information System Study.Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery · 2026Article
- Outcomes of pull-through surgery among children with Hirschsprung's disease in Tanzania: a comparative study.BMC surgery · 2025Article
- Investigating colostomy-related morbidity in children following stoma formation and closure in a tertiary hospital, Abha, Saudi Arabia: a retrospective cohort study 2024.BMC pediatrics · 2024Article
- Controversies in Hirschsprung surgery.World journal of pediatric surgery · 2024Review
- Surgical management of short-segment Hirschsprung disease.World journal of pediatric surgery · 2024Review
- Article
- Regenerative medicine: current research and perspective in pediatric surgery.Pediatric surgery international · 2023Review
- Childhood colostomies: patterns, indications and outcomes in a Nigerian University Teaching Hospital.African health sciences · 2022Article
- Risk factors of enterostomy in neonates with Hirschsprung disease.International journal of colorectal disease · 2022Article
- Clinical outcomes and risk factors for postoperative complications in children with Hirschsprung's disease.American journal of translational research · 2022Article
- The incidence of different forms of ileus following surgery for abdominal birth defects in infants: a systematic review with a meta-analysis method.Innovative surgical sciences · 2021Article
- Early and long-term complications following transanal pull through Soave technique in infants with Hirschsprung's disease.Medicine and pharmacy reports · 2019Article
- Induced pluripotent stem cells for disease modeling, cell therapy and drug discovery in genetic autonomic disorders: a review.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2019Review
- Neural Crest Cell Implantation Restores Enteric Nervous System Function and Alters the Gastrointestinal Transcriptome in Human Tissue-Engineered Small Intestine.Stem cell reports · 2017Article
- A 5-year follow-up study of neonates with Hirschsprung's disease undergoing transanal Soave or Swenson surgery.Patient preference and adherence · 2017Article
- Congenital anomaly rectified at birth: one-stage single-incision laparoscopic-assisted anorectoplasty for newborns with anorectal malformations and recto-urethral fistula.Surgical endoscopy · 2016Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
Abstract
purposeThe aim of this study was to evaluate surgical treatments and outcomes in a multi-institutional cohort of neonates with Hirschsprung's disease (HD).
methodsUsing the Pediatric Health Information System (PHIS) from 1999 to 2009, neonates diagnosed with HD were identified and classified as having a single stage pull-through (SSPT) or multi-stage pull-through (MSPT). Diagnosis and classification algorithms and clinical variables and outcomes were validated by multi-institutional chart review. Groups were compared using logistic regression modeling and propensity-score matched analysis to account for baseline differences between groups.
results1555 neonates with HD were identified; 77.2% underwent SSPT and 22.8% underwent MSPT. Misclassification of disease or surgical treatment was <2%. Rates of SSPT increased over time (p=0.03). Compared to SSPT, patients undergoing MSPT had significantly lower birth weights and higher rates of prematurity, non-HD gastrointestinal anomalies, enterocolitis, and preoperative mechanical ventilation. Patients undergoing MSPT had significantly higher rates of readmissions (58.5 vs. 37.9%) and additional operations (38.7 vs. 26%). Results were consistent in the propensity-score matched analysis.
conclusionMost neonates with HD undergo SSPT. In patients with similar observed baseline characteristics, MSPT was associated with worse outcomes suggesting that some infants currently selected to undergo MSPT may have better outcomes with SSPT. However, there remains a subgroup of MSPT patients who were too ill to be adequately compared to SSPT patients; for this subgroup of severely ill infants with HD, MSPT may be the best option.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.