ArticleScientific reports2014
Homotypic NK cell-to-cell communication controls cytokine responsiveness of innate immune NK cells.
Article in Scientific reports, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
22 citing papers in PubMed, 34 citations in OpenAlex.
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- Graph-Based 3-Dimensional Spatial Gene Neighborhood Networks of Single Cells in Gels and Tissues.BME frontiers · 2025Article
- Identification of the gene signatures related to NK/T cell communication to evaluate the tumor microenvironment and prognostic outcomes of patients with prostate adenocarcinoma.Frontiers in immunology · 2025Article
- Microfluidics-assisted fabrication of natural killer cell-laden microgel enhances the therapeutic efficacy for tumor immunotherapy.Materials today. Bio · 2024Article
- Networked Cluster Formation via Trigonal Lipid Modules for Augmented Ex Vivo NK Cell Priming.International journal of molecular sciences · 2024Article
- NK cells encapsulated in micro/macropore-forming hydrogels via 3D bioprinting for tumor immunotherapy.Biomaterials research · 2023Article
- NK Cells in Cancer: Mechanisms of Dysfunction and Therapeutic Potential.International journal of molecular sciences · 2023Review
- Differential IL-12 signaling induces human natural killer cell activating receptor-mediated ligand-specific expansion.The Journal of experimental medicine · 2022Article
- Effects of extracellular adhesion molecules on immune cell mediated solid tumor cell killing.Frontiers in immunology · 2022Article
- The Integrated Transcriptome Bioinformatics Analysis Identifies Key Genes and Cellular Components for Spinal Cord Injury-Related Neuropathic Pain.Frontiers in bioengineering and biotechnology · 2020Article
- Semaphorin 7A modulates cytokine-induced memory-like responses by human natural killer cells.European journal of immunology · 2019Article
- A novel dendritic cell-based direct ex vivo assay for detection and enumeration of circulating antigen-specific human T cells.Cytotechnology · 2018Article
- Chronic graft-specific cell-mediated immune response toward candidate xenogeneic biomaterial.Immunologic research · 2018Article
- Tumor-Targeting Anti-CD20 Antibodies MediateFrontiers in immunology · 2018Article
- Expansion of cytotoxic natural killer cells using irradiated autologous peripheral blood mononuclear cells and anti-CD16 antibody.Scientific reports · 2017Article
- Multi-cellular natural killer (NK) cell clusters enhance NK cell activation through localizing IL-2 within the cluster.Scientific reports · 2017Article
- HSV1 MicroRNA Modulation of GPI Anchoring and Downstream Immune Evasion.Cell reports · 2016Article
- Activation by SLAM Family Receptors Contributes to NK Cell Mediated "Missing-Self" Recognition.PloS one · 2016Article
Corrections and comments
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Authors and funding
12 authors at 4 institutions in 2 countries.
Funding
Abstract
While stationary organ cells are in continuous contact with neighboring cells, immune cells circulate throughout the body without an apparent requirement for cell-cell contact to persist in vivo. This study challenges current convention by demonstrating, both in vitro and in vivo, that innate immune NK cells can engage in homotypic NK-to-NK cell interactions for optimal survival, activation, and proliferation. Using a specialized cell-laden microwell approach, we discover that NK cells experiencing constant NK-to-NK contact exhibit a synergistic increase in activation status, cell proliferation, and anti-tumor function in response to IL-2 or IL-15. This effect is dependent on 2B4/CD48 ligation and an active cytoskeleton, resulting in amplification of IL-2 receptor signaling, enhanced CD122/CD132 colocalization, CD25 upregulation, and Stat3 activation. Conversely, 'orphan' NK cells demonstrate no such synergy and fail to persist. Therefore, our data uncover the existence of homotypic cell-to-cell communication among mobile innate lymphocytes, which promotes functional synergy within the cytokine-rich microenvironment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.