ArticleAsian journal of andrology
An epididymis-specific carboxyl esterase CES5A is required for sperm capacitation and male fertility in the rat.
Article in Asian journal of andrology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 19 citations in OpenAlex.
- Male reproductive biology was reshaped during placental mammal diversification through epididymal secretome expansion.EMBO reports · 2026Article
- Investigating Low-Temperature Stress Responses in Crustacea Aquatic Species Through Comparative Transcriptomics.Evolutionary applications · 2026Article
- Signatures of selection inEvolutionary applications · 2024Article
- The proteomic landscape of sperm surface deciphers its maturational and functional aspects in buffalo.Frontiers in physiology · 2024Article
- Unraveling the phenotypic and genomic background of behavioral plasticity and temperament in North American Angus cattle.Genetics, selection, evolution : GSE · 2023Article
- Proteomic Analysis of Intracellular and Membrane-Associated Fractions of Canine (Animals : an open access journal from MDPI · 2022Article
- Estimation of inbreeding and identification of regions under heavy selection based on runs of homozygosity in a Large White pig population.Journal of animal science and biotechnology · 2020Article
- Comparative RNA-Seq Analysis of Differentially Expressed Genes in the Epididymides of Yak and Cattleyak.Current genomics · 2019Article
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Authors and funding
6 authors at 3 institutions in 1 country.
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Abstract
Despite the fact that the phenomenon of capacitation was discovered over half century ago and much progress has been made in identifying sperm events involved in capacitation, few specific molecules of epididymal origin have been identified as being directly involved in this process in vivo . Previously, our group cloned and characterized a carboxyl esterase gene Ces5a in the rat epididymis. The CES5A protein is mainly expressed in the corpus and cauda epididymidis and secreted into the corresponding lumens. Here, we report the function of CES5A in sperm maturation. By local injection of Lentivirus -mediated siRNA in the CES5A -expressing region of the rat epididymis, Ces5a -knockdown animal models were created. These animals exhibited an inhibited sperm capacitation and a reduction in male fertility. These results suggest that CES5A plays an important role in sperm maturation and male fertility.
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