ArticleBMC biology2014
The small protein floodgates are opening; now the functional analysis begins.
Article in BMC biology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed.
- Deeply conserved and expressed small ORFs in the model beetle Tribolium castaneum.BMC biology · 2026Article
- The inhibitory mechanism of a small protein reveals its role in antimicrobial peptide sensing.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Article
- Thousands of small, novel genes predicted in global phage genomes.Cell reports · 2022Article
- Understanding small ORF diversity through a comprehensive transcription feature classification.DNA research : an international journal for rapid publication of reports on genes and genomes · 2021Review
- CdrS Is a Global Transcriptional Regulator Influencing Cell Division in Haloferax volcanii.mBio · 2021Article
- YshB Promotes Intracellular Replication and Is Required forJournal of bacteriology · 2019Article
- Characterization of Three Small Proteins in Brucella abortus Linked to Fucose Utilization.Journal of bacteriology · 2018Article
- Regulation of Proteolysis in the Gram-Negative Bacterial Envelope.Journal of bacteriology · 2018Article
- Comparative Proteomics Enables Identification of Nonannotated Cold Shock Proteins in E. coli.Journal of proteome research · 2017Article
- Conserved small mRNA with an unique, extended Shine-Dalgarno sequence.RNA biology · 2017Article
- Cytotoxic protein from the mushroomProceedings of the National Academy of Sciences of the United States of America · 2017Article
- The developmental proteome ofGenome research · 2017Article
- Translatomics combined with transcriptomics and proteomics reveals novel functional, recently evolved orphan genes in Escherichia coli O157:H7 (EHEC).BMC genomics · 2016Article
- Death of a dogma: eukaryotic mRNAs can code for more than one protein.Nucleic acids research · 2016Review
- The mysterious orphans of Mycoplasmataceae.Biology direct · 2016Article
- Small Open Reading Frames, Non-Coding RNAs and Repetitive Elements in Bradyrhizobium japonicum USDA 110.PloS one · 2016Article
- New genes from non-coding sequence: the role of de novo protein-coding genes in eukaryotic evolutionary innovation.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2015Review
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2 authors.
Funding
Abstract
Aside from a few serendipitous discoveries, small proteins of less than 50 amino acids in bacteria and 100 amino acids in eukaryotes were largely ignored due to challenges in their genetic and biochemical detection. However, with the ever-increasing availability of completed genome sequences and deep sequencing, which allows analysis of genome-wide ribosome occupancy, hundreds of small proteins are now being identified. This brings to the forefront the challenges and opportunities associated with the characterization of these proteins.See research article: http://www.biomedcentral.com/1471-2164/15/946.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.