ReviewCNS neuroscience & therapeutics2015
Targeting the neurovascular unit in brain trauma.
Review in CNS neuroscience & therapeutics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed.
- NEURODEVELOPMENTAL DISRUPTION INDUCED BY LONG-TERM LOW-DOSE HERBICIDE EXPOSURE: BEHAVIORAL AND NEUROPATHOLOGICAL EVIDENCE FROM A RAT MODEL.Farmacia (Bucharest, Romania) · 2026Article
- Raman Spectroscopy Reveals Photobiomodulation-Induced α-Helix to β-Sheet Transition in Tubulins: Potential Implications for Alzheimer's and Other Neurodegenerative Diseases.Nanomaterials (Basel, Switzerland) · 2024Article
- Sleep, inflammation, and hemodynamics in rodent models of traumatic brain injury.Frontiers in neuroscience · 2024Review
- Validation and characterization of a novel blood-brain barrier platform for investigating traumatic brain injury.Scientific reports · 2023Article
- Component-specific reduction in perineuronal nets in senescence-accelerated mouse strains.IBRO neuroscience reports · 2023Article
- Edema after CNS Trauma: A Focus on Spinal Cord Injury.International journal of molecular sciences · 2023Review
- Review
- Nanoparticle-based drug delivery for the treatment of traumatic brain injury.Expert opinion on drug delivery · 2023Review
- Neuroinflammation, Stem Cells, and Stroke.Stroke · 2022Review
- Ultrastructural destruction of neurovascular unit in experimental cervical spondylotic myelopathy.Frontiers in neuroscience · 2022Article
- miR-29c-5p knockdown reduces inflammation and blood-brain barrier disruption by upregulating LRP6.Open medicine (Warsaw, Poland) · 2022Article
- The 100 most-cited articles about the role of neurovascular unit in stroke 2001-2020: A bibliometric analysis.CNS neuroscience & therapeutics · 2021Article
- Protective Effects and Network Analysis of Ginsenoside Rb1 Against Cerebral Ischemia Injury: A Pharmacological Review.Frontiers in pharmacology · 2021Review
- Carbonic Anhydrases as Potential Targets Against Neurovascular Unit Dysfunction in Alzheimer's Disease and Stroke.Frontiers in aging neuroscience · 2021Review
- The AMPAR antagonist perampanel protects the neurovascular unit against traumatic injury via regulating Sirt3.CNS neuroscience & therapeutics · 2021Article
- VEGFD Protects Retinal Ganglion Cells and, consequently, Capillaries against Excitotoxic Injury.Molecular therapy. Methods & clinical development · 2020Article
- Persistent Neurovascular Unit Dysfunction: Pathophysiological Substrate and Trigger for Late-Onset Neurodegeneration After Traumatic Brain Injury.Frontiers in neuroscience · 2020Article
- Serum Exosomal Proteins F9 and TSP-1 as Potential Diagnostic Biomarkers for Newly Diagnosed Epilepsy.Frontiers in neuroscience · 2020Article
- The Medical Management of Cerebral Edema: Past, Present, and Future Therapies.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2019Review
- Membrane transporters in traumatic brain injury: Pathological, pharmacotherapeutic, and developmental implications.Experimental neurology · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
Abstract
Although the neurovascular unit was originally developed as a conceptual framework for stroke, it is now recognized that these cell-cell interactions play critical roles in many other CNS disorders as well. In brain trauma, perturbations within the neurovascular unit may be especially important. Changes in neurovascular coupling may disrupt blood flow and metabolic regulation. Disruption of transmitter release-reuptake kinetics in neurons and astrocytes may augment excitotoxicity. Alterations in gliovascular signaling may underlie blood-brain barrier disruptions and traumatic edema. Perturbations in cell-cell signaling between all neuronal, glial, and vascular compartments may increase susceptibility to cell death. Finally, repairing the brain after trauma requires the integrated restoration of all neural, glial, and vascular connectivity for effective functional recovery. Just as in stroke, saving neurons alone may also be insufficient for treating brain trauma. In this minireview, we attempt to briefly highlight some of these pathways to underscore the importance of rescuing the entire neurovascular unit in brain trauma.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.