Evidence map›Paper›PMID 25475522›Full record

SynthesisCritical care (London, England)2014

Expert consensus and recommendations on safety criteria for active mobilization of mechanically ventilated critically ill adults.

Carol L Hodgson, Kathy Stiller, Dale M Needham, Claire J Tipping, Megan Harrold, Claire E Baldwin, Scott Bradley, Sue Berney, Lawrence R Caruana, Doug Elliott and 13 more

5 registry-linked trialsAbstract readSystematic ReviewConsensus Statement
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Critical care (London, England), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 5 registered trials, which are not on this map. Cited by 219 papers, 14 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
219citing papers in PubMed, 14 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03328767 nacompletednot on this mapstarted 2018, after this paper: background citation

A Pilot Randomised Controlled Trial in Extracorporeal Membrane Oxygenation Physical Training (ECMO-PT)

TypeinterventionalSponsorAustralian and New Zealand Intensive Care Research CentreRan2018 to 2020Enrolled20ConditionsCritically Ill, Mechanically Ventilated, Extracorporeal Membrane Oxygenation ComplicationArmsEarly activity and Mobilisation intervention
NCT04027049 nacompletednot on this mapstarted 2019, after this paper: background citation

Biologic Mechanisms of Early Exercise After Intracerebral Hemorrhage: a Pilot Randomized Controlled Trial of Cycle Ergometry

TypeinterventionalSponsorJohns Hopkins UniversityRan2019 to 2021Enrolled25ConditionsIntracerebral Hemorrhage, Acute Ischemic StrokeArmsSupine cycle ergometry of the lower extremities
NCT05953649 naunknown statusnot on this mapstarted 2023, after this paper: background citation

Effect of Early Extracorporeal Diaphragm Pacing （EDP） Combined With Tilt Table Verticalization （TTV) on Diaphragm Function in Critically Ill Patients With Mechanical Ventilation: a Randomized Controlled Trial.

TypeinterventionalSponsorSun Yat-Sen Memorial Hospital of Sun Yat-Sen UniversityRan2023 to 2024Enrolled90ConditionsEarly Mobilization, Critically Ill, Mechanical Ventilation, Diaphragm DysfunctionArmsExtracorporeal Diaphragm Pacing, Tilt Table Verticalization, Conventional Physiotherapy
NCT06532994 recruitingnot on this mapstarted 2024, after this paper: background citation

Development and Validation of a Prediction Algorithms to Estimate the Clinical Effect of Early Rehabilitation on ICU Survivors Received Mechanical Ventilation in the ICU

TypeobservationalSponsorWuhan UniversityRan2024 to 2026Enrolled250ConditionsIntensive Care, Mechanical Ventilation, Rehabilitation, AlgorithmsArmsEarly rehabilitation intervention
NCT07017517 narecruitingnot on this mapstarted 2026, after this paper: background citation

Effect of Physical Therapy on NLRP3 Inflammasome Activation and Muscle Atrophy in Critical Illness Myopathy (PT-NLRP3-CIM).

TypeinterventionalSponsorUniversity of ChileRan2026 to 2027Enrolled24ConditionsCritical Illness MyopathyArmsMotomed Letto® servo-assisted cycling + standard physiotherapy, Standard physiotherapy
3 · Its place in the literature

Who cites it

219 citing papers in PubMed, 14 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Exercise therapy for the treatment of delirium in the intensive care unit.The Cochrane database of systematic reviews · 2025
    Pooled it
  6. Guideline
  7. Guideline
  8. Guideline
  9. Pooled it
  10. Pooled it
  11. Pooled it
  12. Pooled it
  13. Pooled it
  14. Pooled it
  15. Trial
  16. Trial
  17. Trial
  18. Trial
  19. Trial
  20. Association of Mobilization and Chest Physiotherapy on Weaning Outcome of Prolonged Weaning Subjects: A Retrospective Cohort.Physiotherapy research international : the journal for researchers and clinicians in physical therapy · 2026
    Article

159 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors.

Carol L HodgsonAustralian and New Zealand Intensive Care Research Centre (ANZIC-RC), Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Monash University, 99 Commercial Road, Melbourne, Victoria, 3004, Australia. carol.hodgson@monash.edu.
Kathy StillerDepartment of Physiotherapy, Royal Adelaide Hospital, North Terrace, Adelaide, South Australia, 5000, Australia. kathy.stiller@health.sa.gov.au.
Dale M NeedhamOutcomes After Critical Illness & Surgery (OACIS) Group, Division of Pulmonary & Critical Care Medicine, Department of Physical Medicine & Rehabilitation, Johns Hopkins Hospital, 600 N. Wolfe Street, Meyer 1-130, Baltimore, Maryland, 21287, USA. dale.needham@jhmi.edu.
Claire J TippingDepartment of Physiotherapy, The Alfred, 55 Commercial Road, Melbourne, Victoria, 3004, Australia. c.tipping@alfred.org.au.
Megan HarroldSchool of Physiotherapy & Exercise Science, Curtin University of Technology, Kent Street, Bentley, Western Australia, 6102, Australia. harroldm@hotmail.com.
Claire E BaldwinSchool of Health Sciences, University of South Australia, City East Campus, North Terrace, Adelaide, South Australia, 5001, Australia. claire.baldwin@unisa.edu.au.
Scott BradleyDepartment of Physiotherapy, The Alfred, 55 Commercial Road, Melbourne, Victoria, 3004, Australia. S.Bradley@alfred.org.au.
Sue BerneyPhysiotherapy Department, Austin Hospital, 145 Studley Road, Heidelberg, Victoria, 3084, Australia. Sue.berney@austin.org.au.
Lawrence R CaruanaThe Prince Charles Hospital, 627 Rode Road, Chermside, Queensland, 4032, Australia. Lawrence.Caruana@health.qld.gov.au.
Doug ElliottFaculty of Health, University of Technology, Sydney (UTS), 235 Jones Street, Broadway, New South Wales, 2007, Australia. doug.elliott@uts.edu.au.
Margot GreenPhysiotherapy Department, Canberra Hospital, Yamba Drive, Garran, Australian Capital Territory, 2605, Australia. Margot.Green@act.gov.au.
Kimberley HainesPhysiotherapy Department, Austin Hospital, 145 Studley Road, Heidelberg, Victoria, 3084, Australia. Kimberley.haines@svhm.org.au.
Alisa M HigginsAustralian and New Zealand Intensive Care Research Centre (ANZIC-RC), Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Monash University, 99 Commercial Road, Melbourne, Victoria, 3004, Australia. lisa.higgins@monash.edu.
Kirsi-Maija KaukonenAustralian and New Zealand Intensive Care Research Centre (ANZIC-RC), Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Monash University, 99 Commercial Road, Melbourne, Victoria, 3004, Australia. maija.kaukonen@hus.fi.
Isabel Anne LeditschkeIntensive Care Unit, Canberra Hospital, Yamba Drive, Garran, Australian Capital Territory, 2605, Australia. Anne.Leditschke@act.gov.au.
Marc R NickelsPhysiotherapy Department, Princess Alexandra Hospital, 199 Ipswich Road, Woolloongabba, Queensland, 4102, Australia. marc.nickels@health.qld.gov.au.
Jennifer ParatzBurns, Trauma & Critical Care Research Centre, School of Medicine, The University of Queensland, Department of Intensive Care Medicine, Royal Brisbane and Women's Hospital, Herston, Queensland, 4029, Australia. j.paratz@uq.edu.au.
Shane PatmanSchool of Physiotherapy, The University of Notre Dame Australia, Fremantle Campus, 19 Mouat Street, Fremantle, Western Australia, 6959, Australia. shane.patman@nd.edu.au.
Elizabeth H SkinnerDepartment of Physiotherapy, Western Health, Western Hospital, Gordon Street, Footscray, Victoria, 3011, Australia. elizabeth.skinner@wh.org.au.
Paul J YoungCapital and Coast District Health Board, Intensive Care Unit, Wellington Hospital, Riddiford Street, Wellington, 6021, New Zealand. paul.young@ccdhb.org.nz.
Jennifer M ZanniDepartment of Physical Medicine and Rehabilitation, Johns Hopkins Hospital, 600 N. Wolfe Street, Meyer 1-130, Baltimore, Maryland, 21287, USA. Jzanni1@jhmi.edu.
Linda DenehyDepartment of Physiotherapy, Melbourne School of Health Sciences, The University of Melbourne, Parkville, Victoria, 3010, Australia. l.denehy@unimelb.edu.au.
Steven A WebbAustralian and New Zealand Intensive Care Research Centre (ANZIC-RC), Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Monash University, 99 Commercial Road, Melbourne, Victoria, 3004, Australia. steve.webb@uwa.edu.au.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThe aim of this study was to develop consensus recommendations on safety parameters for mobilizing adult, mechanically ventilated, intensive care unit (ICU) patients.

methodsA systematic literature review was followed by a meeting of 23 multidisciplinary ICU experts to seek consensus regarding the safe mobilization of mechanically ventilated patients.

resultsSafety considerations were summarized in four categories: respiratory, cardiovascular, neurological and other. Consensus was achieved on all criteria for safe mobilization, with the exception being levels of vasoactive agents. Intubation via an endotracheal tube was not a contraindication to early mobilization and a fraction of inspired oxygen less than 0.6 with a percutaneous oxygen saturation more than 90% and a respiratory rate less than 30 breaths/minute were considered safe criteria for in- and out-of-bed mobilization if there were no other contraindications. At an international meeting, 94 multidisciplinary ICU clinicians concurred with the proposed recommendations.

conclusionConsensus recommendations regarding safety criteria for mobilization of adult, mechanically ventilated patients in the ICU have the potential to guide ICU rehabilitation whilst minimizing the risk of adverse events.

Indexed as

ConsensusCritical CareCritical IllnessEarly AmbulationFemaleHumansMalePatient SafetyPractice Guidelines as TopicRespiration, Artificial

Identifiers

PMID25475522
PMCPMC4301888

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.