ArticleMolecular imaging and biology2015
Quantitative SPECT/CT Imaging of (177)Lu with In Vivo Validation in Patients Undergoing Peptide Receptor Radionuclide Therapy.
Article in Molecular imaging and biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed.
- Quantitative SPECT/CT: Technique and Clinical Applications.Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer · 2026Review
- Quantitative 177Lu-DOTATATE SPECT/CT is predictive of 6-month PRRT morphological response in midgut neuroendocrine tumors: a pilot study.EJNMMI research · 2025Article
- Lutetium-177-Prostate-Specific Membrane Antigen Radioligand Therapy: What Is the Value of Post-Therapeutic Imaging?Biomedicines · 2024Review
- Performance study of a 360° CZT camera for monitoringEJNMMI physics · 2023Article
- Validation ofEJNMMI physics · 2023Article
- Towards accurateEJNMMI physics · 2023Article
- Reconstructed SPECT images ofScientific data · 2022Article
- EANM dosimetry committee recommendations for dosimetry of 177Lu-labelled somatostatin-receptor- and PSMA-targeting ligands.European journal of nuclear medicine and molecular imaging · 2022Article
- The magnitude of the partial volume effect in SPECT imaging of the kidneys: a phantom study.EJNMMI physics · 2022Article
- Optimization of SPECT/CT imaging protocols for quantitative and qualitativeEJNMMI physics · 2021Article
- A multicentre and multi-national evaluation of the accuracy of quantitative Lu-177 SPECT/CT imaging performed within the MRTDosimetry project.EJNMMI physics · 2021Article
- The effect of calibration factors and recovery coefficients onEJNMMI physics · 2021Article
- Comparison of commercial dosimetric software platforms in patients treated withMedical physics · 2020Article
- Three-dimensional Monte Carlo-based voxel-wise tumor dosimetry in patients with neuroendocrine tumors who underwentAnnals of nuclear medicine · 2020Article
- Implementation of patient dosimetry in the clinical practice after targeted radiotherapy using [EJNMMI research · 2018Article
- Dosimetry methods and clinical applications in peptide receptor radionuclide therapy for neuroendocrine tumours: a literature review.EJNMMI research · 2018Review
- Determination of gamma camera calibration factors for quantitation of therapeutic radioisotopes.EJNMMI physics · 2018Article
- Deadtime effects in quantification ofEJNMMI physics · 2018Article
- Accuracy ofEJNMMI physics · 2017Article
- Accuracy and precision assessment for activity quantification in individualized dosimetry ofEJNMMI physics · 2017Article
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4 authors.
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Abstract
purposeThe purpose of this study is to extend an established SPECT/CT quantitation protocol to (177)Lu and validate it in vivo using urine samples, thus providing a basis for 3D dosimetry of (177)Lu radiotherapy and improvement over current planar methods which improperly account for anatomical variations, attenuation, and overlapping organs. PROCEDURES: In our quantitation protocol, counts in images reconstructed using an ordered subset-expectation maximization algorithm are converted to kilobecquerels per milliliter using a calibration factor derived from a phantom experiment. While varying reconstruction parameters, we tracked the ratio of image to true activity concentration (recovery coefficient, RC) in hot spheres and a noise measure in a homogeneous region. The optimal parameter set was selected as the point where recovery in the largest three spheres (16, 8, and 4 ml) stagnated, while the noise continued to increase. Urine samples were collected following 12 SPECT/CT acquisitions of patients undergoing [(177)Lu]DOTATATE therapy, and activity concentrations were measured in a well counter. Data was reconstructed using parameters chosen in the phantom experiment, and estimated activity concentration from the images was compared to the urine values to derive RCs.
resultsIn phantom data, our chosen parameter set yielded RCs in 16, 8, and 4 ml spheres of 80.0, 74.1, and 64.5 %, respectively. For patients, the mean bladder RC was 96.1 ± 13.2% (range, 80.6-122.4 %), with a 95 % confidence interval between 88.6 and 103.6 %. The mean error of SPECT/CT concentrations was 10.1 ± 8.3% (range, -19.4-22.4 %).
conclusionsOur results show that quantitative (177)Lu SPECT/CT in vivo is feasible but could benefit from improved reconstruction methods. Quantifying bladder activity is analogous to determining the amount of activity in the kidneys, an important task in dosimetry, and our results provide a useful benchmark for future efforts.
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