ReviewUrolithiasis2015
Vascular theory of the formation of Randall plaques.
Review in Urolithiasis, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Association between the triglyceride-glucose index and kidney stone disease: a systematic review and dose-response meta-analysis.Lipids in health and disease · 2026Pooled it
- Subclinical papillary tip calcifications in stone-naïve kidneys: micro-ct quantification, osteopontin expression, and associations with urinary and clinical risk factors.Urolithiasis · 2025Article
- Statin Therapy as a Preventive Strategy for Nephrolithiasis: A Review of Current Evidence.Cureus · 2025Review
- Associations of triglyceride glucose-related parameters with kidney stones: a cross-sectional study from NHANES 2007-2020.Translational andrology and urology · 2025Article
- Prolyl hydroxylase domain inhibitors prevent kidney crystal formation by suppressing inflammation.Urolithiasis · 2024Article
- Genetic insights into kidney stone formation: a Mendelian randomization study of protein quantitative trait loci.Urolithiasis · 2024Article
- Osteogenic-Like Microenvironment of Renal Interstitium Induced by Osteomodulin Contributes to Randall's Plaque Formation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Understanding formation processes of calcareous nephrolithiasis in renal interstitium and tubule lumen.Journal of cellular and molecular medicine · 2024Review
- Link Between Obstructive Sleep Apnea and Kidney Stones: NHANES 2015-2018 and Mendelian Randomization.Nature and science of sleep · 2024Article
- Nephrolithiasis is associated with the severity of coronary artery calcification, but not with coronary artery stenosis.World journal of urology · 2023Article
- Association between aortic calcification and the presence of kidney stones: calcium oxalate calculi in focus.International urology and nephrology · 2022Article
- The Pulp Stones: Morphological Analysis in Scanning Electron Microscopy and Spectroscopic Chemical Quantification.Medicina (Kaunas, Lithuania) · 2021Article
- The relationship between vascular calcifications and urolithiasis in a large, multiethnic patient population.Urolithiasis · 2021Article
- The Activation of ROS/NF-Oxidative medicine and cellular longevity · 2021Article
- Elevated non-high-density lipoprotein cholesterol corresponds to a high risk of nephrolithiasis in children.BMC urology · 2020Article
- Calcium Kidney Stones are Associated with Increased Risk of Carotid Atherosclerosis: The Link between Urinary Stone Risks, Carotid Intima-Media Thickness, and Oxidative Stress Markers.Journal of clinical medicine · 2020Article
- [Current concepts on the pathogenesis of urinary stones].Der Urologe. Ausg. A · 2019Review
- Association of sirtuin 1 gene polymorphisms with nephrolithiasis in Eastern chinese population.Renal failure · 2019Article
- Activation of liver X receptor suppresses osteopontin expression and ameliorates nephrolithiasis.Journal of cellular physiology · 2019Article
- Mice with a Brd4 Mutation Represent a New Model of Nephrocalcinosis.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2019Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The relationship between calcium-based calculi and Randall plaques is well documented, but the role these plaques play in the early process of urinary stone formation remains unknown. The vascular hypothesis of Randall plaque formation has been proposed, and recent works support this concept. The renal papilla's vascular environment is subject to relative hypoxia, hyperosmolar surroundings, and turbulent blood flow. These factors together create an environment prone to vascular injury and may potentiate Randall plaque precipitation. Recent data support the similarity between the vascular calcification process itself and urinary stone formation. Furthermore, epidemiological studies have suggested an association between urinary stones, adverse cardiovascular events, and vascular calcification risk factors. The concept that an initial vascular insult precipitates a Randall plaque and subsequent urolithiasis is compelling and represents an area in need of continued research. This may lead to future novel treatment approaches to urolithiasis.
Indexed as
Identifiers
25475492What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.