ArticleInternational psychogeriatrics2015
Disability but not social support predicts cognitive deterioration in late-life depression.
Article in International psychogeriatrics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
7 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.
- Functional social support and cognitive function in middle- and older-aged adults: a systematic review of cross-sectional and cohort studies.Systematic reviews · 2023Pooled it
- The reciprocal relationship between depression and disability in low-income homebound older adults following tele-depression treatment.International journal of geriatric psychiatry · 2021Trial
- Risk Factors Influencing Cognitive Function in Elderly Patients With Late-Life Depression: A Scoping Review.Brain and behavior · 2025Article
- Evaluation of the relationship between body composition and dietary habits of physically active people with disabilities.Scientific reports · 2024Article
- Cognitive phenotypes in late-life depression.International psychogeriatrics · 2023Observational
- Operationalizing Social Environments in Cognitive Aging and Dementia Research: A Scoping Review.International journal of environmental research and public health · 2021Article
- Cognitive performance in antidepressant-free recurrent major depressive disorder.Depression and anxiety · 2018Article
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Authors and funding
5 authors at 5 institutions in 1 country.
Funding
Abstract
backgroundDepression in late life is a risk factor for cognitive decline. Depression is also associated with increased disability and social support deficits; these may precede conversion to dementia and inform risk. In this study, we examined if baseline or one-year change in disability and social support predicted later cognitive deterioration.
methods299 cognitively intact depressed older adults were followed for an average of approximately seven years. Participants received antidepressant treatment according to a standardized algorithm. Neuropsychological testing and assessment of disability and social support were assessed annually. Cognitive diagnosis was reviewed annually at a consensus conference to determine if participants remained cognitively normal, or if they progressed to either dementia or cognitively impaired, no dementia (CIND).
resultsDuring study participation, 167 individuals remained cognitively normal (56%), 83 progressed to CIND (28%), and 49 progressed to dementia (16%). Greater baseline instrumental activities of daily living (IADL) deficits predicted subsequent conversion to a cognitive diagnosis (CIND or dementia). However, neither baseline measures nor one-year change in basic ADLs (BADLs) and social support predicted cognitive conversion. In post hoc analyses, two IADL measures (managing finances, preparing meals) significantly increased the odds of cognitive conversion.
conclusionsGreater IADL deficits predicted increased risk of cognitive conversion. Assessment of IADL deficits may provide clues about risk of later cognitive decline.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.