ArticleJournal of neurophysiology2015
Glutamate receptors in the hypothalamic paraventricular nucleus contribute to insulin-induced sympathoexcitation.
Article in Journal of neurophysiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 26 citations in OpenAlex.
- Role of the carotid chemoreceptors in insulin-mediated sympathoexcitation in humans.American journal of physiology. Regulatory, integrative and comparative physiology · 2020Trial
- Metabolic control of ovarian function through the sympathetic nervous system: role of leptin.Frontiers in endocrinology · 2024Review
- Effects of Puberty on Blood Pressure Trajectories - Underlying Processes.Current hypertension reports · 2023Review
- Metformin effectively restores the HPA axis function in diet-induced obese rats.International journal of obesity (2005) · 2021Article
- Role of Hyperinsulinemia and Insulin Resistance in Hypertension: Metabolic Syndrome Revisited.The Canadian journal of cardiology · 2020Review
- Obesity: sex and sympathetics.Biology of sex differences · 2020Review
- Sites and sources of sympathoexcitation in obese male rats: role of brain insulin.American journal of physiology. Regulatory, integrative and comparative physiology · 2020Article
- Circadian-timed quick-release bromocriptine lowers elevated resting heart rate in patients with type 2 diabetes mellitus.Endocrinology, diabetes & metabolism · 2020Article
- Sex differences in the sympathoexcitatory response to insulin in obese rats: role of neuropeptide Y.The Journal of physiology · 2019Article
- Central Administration of Insulin Combined With Resistin Reduces Renal Sympathetic Nerve Activity in Rats Fed a High Fat Diet.Frontiers in physiology · 2019Article
- Quantifying Acute Changes in Renal Sympathetic Nerve Activity in Response to Central Nervous System Manipulations in Anesthetized Rats.Journal of visualized experiments : JoVE · 2018Article
- Airway obstruction produces widespread sympathoexcitation: role of hypoxia, carotid chemoreceptors, and NTS neurotransmission.Physiological reports · 2018Article
- The normal increase in insulin after a meal may be required to prevent postprandial renal sodium and volume losses.American journal of physiology. Regulatory, integrative and comparative physiology · 2017Article
- Insulin increases sympathetic nerve activity in part by suppression of tonic inhibitory neuropeptide Y inputs into the paraventricular nucleus in female rats.American journal of physiology. Regulatory, integrative and comparative physiology · 2016Article
- Obesity-Induced Hypertension: Brain Signaling Pathways.Current hypertension reports · 2016Review
- Cardiovascular Regulation by the Arcuate Nucleus of the Hypothalamus: Neurocircuitry and Signaling Systems.Hypertension (Dallas, Tex. : 1979) · 2016Review
- Central Administration of Insulin and Leptin Together Enhance Renal Sympathetic Nerve Activity and Fos Production in the Arcuate Nucleus.Frontiers in physiology · 2016Article
- Role of the Paraventricular Nucleus of the Hypothalamus in the Sympathoexcitatory Effects of Leptin.Hypertension (Dallas, Tex. : 1979) · 2015Article
- Selective C1 Lesioning Slightly Decreases Angiotensin II Type I Receptor Expression in the Rat Rostral Ventrolateral Medulla (RVLM).Neurochemical research · 2015Article
- Hypothalamic signaling mechanisms in hypertension.Current hypertension reports · 2015Review
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The sympathoexcitatory response to insulin is mediated by neurons in the arcuate nucleus (ARC) and hypothalamic paraventricular nucleus (PVH). Previous studies have reported that stimulation of ARC neurons increases sympathetic nerve activity (SNA) and arterial blood pressure (ABP) through glutamate receptor activation in the PVH. Therefore, the purpose of the present study was to determine whether glutamatergic neurotransmission in the PVH contributes to insulin-induced sympathoexcitation. Male Sprague-Dawley rats (275-400 g) were infused with isotonic saline or insulin (3.75 mU · kg(-1) · min(-1)) plus 50% dextrose to maintain euglycemia. Intravenous infusion of insulin significantly increased lumbar SNA without a significant change in mean ABP, renal SNA, heart rate, or blood glucose. Bilateral PVH injection of the excitatory amino acid antagonist kynurenic acid (KYN) lowered lumbar SNA and ABP of animals infused with insulin. Similarly, a cocktail of the NMDA antagonist DL-2-amino-5-phosphonopentanoic acid (AP5) and non-NMDA antagonist 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX) reduced lumbar SNA and mean ABP during infusion of insulin. In a final experiment, bilateral PVH injection of AP5 only, but not CNQX, lowered lumbar SNA and mean ABP of animals infused with insulin. The peak changes in lumbar SNA and mean ABP of insulin-treated animals were not different between KYN, AP5 plus CNQX, or AP5 alone. These drug treatments did not alter any variable in animals infused with saline. Altogether, these findings suggest that glutamatergic NMDA neurotransmission in the PVH contributes to insulin-induced sympathoexcitation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.