ArticleJournal of translational medicine2014
Endometrial regenerative cells as a novel cell therapy attenuate experimental colitis in mice.
Article in Journal of translational medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.
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Who cites it
33 citing papers in PubMed, 1 synthesis or guideline pooled it, 57 citations in OpenAlex.
- The Use of Human Mesenchymal Stem Cells as Therapeutic Agents for theFrontiers in immunology · 2018Pooled it
- The crosstalk between exosomes and ferroptosis: a review.Cell death discovery · 2024Review
- Potential shared pathogenic mechanisms between endometriosis and inflammatory bowel disease indicate a strong initial effect of immune factors.Frontiers in immunology · 2024Article
- CD73 mediates the therapeutic effects of endometrial regenerative cells in concanavalin A-induced hepatitis by regulating CD4Stem cell research & therapy · 2023Article
- Menstrual blood-derived endometrial stem cells alleviate neuroinflammation by modulating M1/M2 polarization in cell and rat Parkinson's disease models.Stem cell research & therapy · 2023Article
- IL-37 overexpression promotes endometrial regenerative cell-mediated inhibition of cardiac allograft rejection.Stem cell research & therapy · 2022Article
- Endometrial Regenerative Cell-Derived Exosomes Attenuate Experimental Colitis through Downregulation of Intestine Ferroptosis.Stem cells international · 2022Article
- IL-1β pre-stimulation enhances the therapeutic effects of endometrial regenerative cells on experimental colitis.Stem cell research & therapy · 2021Article
- Culture density of menstrual blood-derived stromal/stem cells determines the quality of T cell responses: An experimental study.International journal of reproductive biomedicine · 2021Article
- Menstrual blood-derived stromal cells modulate functional properties of mouse and human macrophages.Scientific reports · 2020Article
- Therapeutic potential of menstrual blood stem cells in treating acute liver failure.World journal of gastroenterology · 2019Article
- SDF-1/CXCR4 axis enhances the immunomodulation of human endometrial regenerative cells in alleviating experimental colitis.Stem cell research & therapy · 2019Article
- Therapeutic potential of menstrual blood-derived endometrial stem cells in cardiac diseases.Cellular and molecular life sciences : CMLS · 2019Review
- Human menstrual blood-derived stem cells protect H9c2 cells against hydrogen peroxide-associated apoptosis.In vitro cellular & developmental biology. Animal · 2019Article
- PD-L1 is required for human endometrial regenerative cells-associated attenuation of experimental colitis in mice.American journal of translational research · 2019Article
- Unraveling the Molecular Signature of Extracellular Vesicles From Endometrial-Derived Mesenchymal Stem Cells: Potential Modulatory Effects and Therapeutic Applications.Frontiers in bioengineering and biotechnology · 2019Article
- Human menstrual blood: a renewable and sustainable source of stem cells for regenerative medicine.Stem cell research & therapy · 2018Review
- Treatment of experimental colitis by endometrial regenerative cells through regulation of B lymphocytes in mice.Stem cell research & therapy · 2018Article
- The Clinical Applications of Endometrial Mesenchymal Stem Cells.Biopreservation and biobanking · 2018Review
- Oral Escherichia coli expressing IL-35 meliorates experimental colitis in mice.Journal of translational medicine · 2018Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundEndometrial regenerative cells (ERCs) are mesenchymal-like stem cells that can be non-invasively obtained from menstrual blood and are easily grown /generated at a large scale without tumorigenesis. We previously reported that ERCs exhibit unique immunoregulatory properties in vitro, however their immunosuppressive potential in protecting the colon from colitis has not been investigated. The present study was undertaken to determine the efficacy of ERCs in mediating immunomodulatory functions against colitis.
methodsColitis was induced by 4% dextran-sulfate-sodium (DSS, in drinking water) in BALB/c mice for 7 days. ERCs were cultured from healthy female menstrual blood, and injected (1 million/mouse/day, i.v.) into mice on days 2, 5, and 8 following colitis induction. Colonic and splenic tissues were collected on day 14 post-DSS-induction. Clinical signs, disease activity index (DAI), pathological and immunohistological changes, cytokine profiles and cell populations were evaluated.
resultsDSS-induced mice in untreated group developed severe colitis, characterized by body-weight loss, bloody stool, diarrhea, mucosal ulceration and colon shortening, as well as pathological changes of intra-colon cell infiltrations of neutrophils and Mac-1 positive cells. Notably, ERCs attenuated colitis with significantly reduced DAI, decreased levels of intra-colon IL-2 and TNF-α, but increased expressions of IL-4 and IL-10. Compared with those of untreated colitis mice, splenic dendritic cells isolated from ERC-treated mice exhibited significantly decreased MHC-II expression. ERC-treated mice also demonstrated much less CD3(+)CD25(+) active T cell and CD3(+)CD8(+) T cell population and significantly higher level of CD4(+)CD25(+)Foxp3(+) Treg cells.
conclusionsThis study demonstrated novel anti-inflammatory and immunosuppressive effects of ERCs in attenuating colitis in mice, and suggested that the unique features of ERCs make them a promising therapeutic tool for the treatment of ulcerative colitis.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.