Evidence map›Paper›PMID 25475183›Full record

ArticleNeuron2014

A precisely defined role for the tip link-associated protein TMIE in the mechanoelectrical transduction channel complex of inner ear hair cells.

Wolfgang Liedtke

Open access · bronzeAbstract readComment
PubMed Publisher
In one paragraph

Article in Neuron, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Wolfgang LiedtkeDuke University Departments of Neurology, Neurobiology and Anesthesiology, Duke University Clinics for Pain and Palliative Care, Durham, NC 27710, USA. Electronic address: wolfgang@neuro.duke.edu.
Duke University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Inner ear hair cells transduce sound waves and acceleration. In the quest to identify the molecular machinery underlying mechanoelectrical transduction, Zhao et al. (2014) in this issue of Neuron reveal that the TMIE protein, essential for hearing, physically interacts with tip link protein protocadherin-15.

Indexed as

AnimalsCadherin Related ProteinsCadherinsHair Cells, AuditoryHumansMechanotransduction, CellularMembrane ProteinsProtein PrecursorsCadherin Related ProteinsCadherinsCDHR15 protein, mouseMembrane ProteinsProtein PrecursorsTmie protein, mouse

Identifiers

PMID25475183
OpenAlexW2047177637

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.